1. Amino acid side chains act as nucleophiles and proton donor/acceptors in various enzymatic reactions. We will use them frequently in reactions during 40B and therefore the purpose of this exercise is to review the properties of amino acid side chains you have learned in 40A. Ozempic is a medication used for the treatment of type 2 diabetes and an anti-obesity treatment. Ozempic is a modified peptide that mimics the structure of the natural hormone GLP-1. a. -lle Ala Trp Leu -Val-Arg-Gly Arg Gly-OH Add above the tree-letter code of each amino acid the relevant functional group on its side chain. OH For example: -Ser- will be represented by Ser The Phe Thr-Ser Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gily Gin-Ala-Ala-NouPre-e- детави C. b. The protonation state of each functional group depends on the pH of the solution. Assume that Ozempic is in a solution at pH=7. Draw the functional groups at their correct protonation form. Gu-Gy Th Phe Thr-Ser Asp-Val-Ser-Ser-Tyr-Leu-Glu Gly Gin Ala Ala- MC CH₂ thora Nlcm Gu Phe-e Ala Tip Leu-Val Arg-Gly Arg-Gly-OH OH What will be the protonation state of the long non-peptide side chain at pH=7?
1. Amino acid side chains act as nucleophiles and proton donor/acceptors in various enzymatic reactions. We will use them frequently in reactions during 40B and therefore the purpose of this exercise is to review the properties of amino acid side chains you have learned in 40A. Ozempic is a medication used for the treatment of type 2 diabetes and an anti-obesity treatment. Ozempic is a modified peptide that mimics the structure of the natural hormone GLP-1. a. -lle Ala Trp Leu -Val-Arg-Gly Arg Gly-OH Add above the tree-letter code of each amino acid the relevant functional group on its side chain. OH For example: -Ser- will be represented by Ser The Phe Thr-Ser Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gily Gin-Ala-Ala-NouPre-e- детави C. b. The protonation state of each functional group depends on the pH of the solution. Assume that Ozempic is in a solution at pH=7. Draw the functional groups at their correct protonation form. Gu-Gy Th Phe Thr-Ser Asp-Val-Ser-Ser-Tyr-Leu-Glu Gly Gin Ala Ala- MC CH₂ thora Nlcm Gu Phe-e Ala Tip Leu-Val Arg-Gly Arg-Gly-OH OH What will be the protonation state of the long non-peptide side chain at pH=7?
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter4: Cells
Section: Chapter Questions
Problem 1ITD
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