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1. The enzyme glutamate dehydrogenase is important in the breakdown of amino acids to produce NH4+. High levels of NH4+ in the body are toxic, and for this reason it is used to form urea to be excreted in the urine. a) Using the information provided, calculate the delta G knot prime and the Keq value at 298K for the oxidation of glutamate catalyzed by glutamate dehydrogenase. (Constants: R=8.3J/degree.mol, F=96.1kJ/V.mol) b) Given the reaction above, why would high levels of NH4+ be toxic?

1. The enzyme glutamate dehydrogenase is important in the breakdown of amino acids to produce NH4+. High levels of NH4+ in the body are toxic, and for this reason it is used to form urea to be excreted in the urine. a) Using the information provided, calculate the delta G knot prime and the Keq value at 298K for the oxidation of glutamate catalyzed by glutamate dehydrogenase. (Constants: R=8.3J/degree.mol, F=96.1kJ/V.mol) b) Given the reaction above, why would high levels of NH4+ be toxic?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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1. The enzyme glutamate dehydrogenase is important in the breakdown of amino acids to produce NH4+. High levels of NH4+ in the body are toxic, and for this reason it is used to form urea to be excreted in the urine.

a) Using the information provided, calculate the delta G knot prime and the Keq value at 298K for the oxidation of glutamate catalyzed by glutamate dehydrogenase. (Constants: R=8.3J/degree.mol, F=96.1kJ/V.mol)

b) Given the reaction above, why would high levels of NH4+ be toxic?

c) Given the reaction above, explain how a high concentration of gutamate inside the cell would affect energy production. Be sure to be specific.

→ ubiquinol + Glutamate + H20 E0'= -0.140 V ubiquinone +2H* +2e- E0'= +0.045 V a-Ketoglutarate +NH4* +2H* +2e- NAD* +2H* +2e- → NADH + H* E0'= -0.320 V a-Ketoglutarate +CO2 +2H* +2e- → isocitrate E0'= -0.380 V
Transcribed Image Text:→ ubiquinol + Glutamate + H20 E0'= -0.140 V ubiquinone +2H* +2e- E0'= +0.045 V a-Ketoglutarate +NH4* +2H* +2e- NAD* +2H* +2e- → NADH + H* E0'= -0.320 V a-Ketoglutarate +CO2 +2H* +2e- → isocitrate E0'= -0.380 V
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