Dosage forms

Based on United State Pharmacopeia, pastes are defined as semisolid dosage forms that contain one or more drug substances intended for topical application. (Pharmaceutical Dosage Form, 2009) Pastes are intended for application to the skin, oral cavity, or mucous membranes. Pastes are usually prepared from fats, fatty oils, petrolatum, paraffin, waxes, glycerin or water by mixing homogeneously powdered drug with the foregoing materials as bases. (General Requirements for Pharmaceutical Preparation)

improved therapeutic advantage. Drug absorption in GIT varies and increased gastric retention time of the dosage form extends the time of drug absorption. It is one of the novel drug delivery system to prolong gastric residence time. Thereby implementing site specific drug release in the stomach for local and systemic effect. It is very useful for the drugs which having narrow absorption Rate. Various forms of gastro retentive drug delivery system , such as floating and non-floating. This article can give

AR/LR : Analytical reagent/Laboratory reagent CDR : Cumulative drug release FTIR : Fourier Transform Infrared spectroscopy ICH : International Conference for Harmonization Mg : Milligram ODT : Orally disintegrating

explored nano sized drug delivery systems. They posses potentials for myriad applications such as targeting DD, controlled DD, absorption enhancement (Müller, Radtke et al. 2002). They can be formulated in most of treatment routes, from topical dosage forms to brain drug delivery. Because of their lipophilic nature, lipid nanoparticles have great potential to incorporate sparingly soluble APIs to modulate therapies. Lipid nanoparticles preparation can be categorized into solvent based or non-solvent

Transmucosal route of drug delivery is widely accepted as a suitable way for administration of drugs via buccal mucosa for local and systemic applications. Compared to other transmucosal routes, buccal mucosa is approximately an immobile, highly accessible mucosa that characterized by wide area of smooth muscles1. Moreover, buccal drug delivery systems offer various advantages including the direct entry to the systemic circulation through the internal jugular vein avoiding first pass metabolism and

Aim: The aim of this work was preparing once daily fast disintegrating tablets to handle easily for adult hypertensive patients who have difficulty in swallowing. Methods: Solid dispersions bisoprolol hemifumarate (SD-BH) was prepared by using EC and HPMC in different ratios. A 3* 22 full factorial design was used to investigate the main formulation parameters (different fillers, binder differ in the molecular weight and different coat type). SD-BH were prepared and characterized by DSC. Disintegration

the popularity of controlled release technology in the delivery of drugs. When the pellets containing active ingredient are administered in-vivo in the form of suspensions, capsules, or disintegrating tablets, they offer significant therapeutic advantages over single unit dosage forms, since pellets

DEVELOPMENT & EVALUATION OF FAST DISINTEGRATING FILMS AND TABLETS OF VALSARTAN G.Sandhyarani 1,M.Madhuri 2 1,2 vaageswari college of pharmacy,Karimnager Corresponding Author:Sandhyaguggilla9@gmail.com Abstract Orodispersible dosage forms are used for accurate dosing, enhanced bioavailability, rapid action, patient compliance, easy of administration, enhanced palatability. Valsartan is a specific and selective type-1 angiotensin II receptor antagonist which blocks the blood pressure

DESIGN FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF STAVUDINE Mourya Adarsh*, Mrs.P. Haritha Sunil*, Praveen Kanna, Sampath.M Department of Pharmaceutics, St.Pauls College of Pharmacy, Hayathnagar, Telangana, India Abstract: The purpose of the present research work was to design, formulate and evaluate the floating tablets of Stavudine, a gastro retentive drug delivery system. Direct compression was used to prepare the tablets using HPMC K4M, HPMC K15M and Carbopol 974(p) as

administration of pure Candesartan, Candesartan conventional capsule dosage form and Candesartan optimized formulation (Run 18) are given in Table 16. A comparative mean plasma concentration-time curve of pure Candesartan, Candesartan conventional capsule dosage form and Candesartan optimized formulation (Run 18) are illustrated in Fig.14. The mean pharmacokinetic parameters of the pure Candesartan, Candesartan conventional capsule dosage form and Candesartan optimized formulation (Run 18) were estimated