Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter CHST1, Problem 1DQ
Imprinting disorders do not involve changes in DNA sequence, but only the methylated state of the DNA, or the modification of histones. Does it seem likely that imprinting disorders could be treated prenatally or prevented by controlling the maternal environment in some way, perhaps by dietary changes?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
How would you explain gene expression? How is it that a particular genotype is actually
expressed as a phenotype? I am looking for details here, including an explanation of the
molecular mechanisms involved.
Duchenne Muscular Dystrophy (DMD) is a disease that manifests in muscle weakness. It exhibits X-linked recessive inheritance pattern. The dystrophin gene is large and can have many different mutations along the DNA.
From the following mutations between the gene sequence (DNA template strand) of a healthy male and an affected brother determine if they would affect the production of mRNA or the sequence of the protein.
Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons.
Mutation 1:
Position -6
Healthy individual A
Affected brother C
Group of answer choices
A. Normal mRNA, normal protein
B. No mRNA produced (promoter affected)
C. Abnormal mRNA, affected protein
D. Normal mRNA, affected protein
Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons.
Explain maternal-effect mutations?
Chapter CHST1 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. CHST1 - What are the major mechanisms of epigenetic genome...Ch. CHST1 -
2. What parts of the genome are reversibly...Ch. CHST1 - What are the roles of proteins in histone...Ch. CHST1 - Describe how reversible chemical changes to...Ch. CHST1 -
5. What is the histone code?
Ch. CHST1 - Prob. 6RQCh. CHST1 - Why are changes in nucleosome spacing important in...Ch. CHST1 -
8. How do microRNAs regulate epigenetic...Ch. CHST1 - What is the role of imprinting in human genetic...Ch. CHST1 - Imprinting disorders do not involve changes in DNA...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- "In most differentiated tissues, daughter cells retain a memory of gene expression patterns that were present in the parent cell through mechanisms that do not involve changes in the sequence of their genomic DNA" is true or false.arrow_forward1) using at least one named example discuss the implication of allelic heterogeneity in single gene disorder for the presentation and progession of the disorder and its treatment 2) discuss the importance of understanding epigenetics in improving people healtharrow_forwardOur understanding of maternal effect genes has been greatly aided by their identification in experimental organisms such as Drosophila melanogaster and Caenorhabditis elegans. In experimental organisms with a short generation time, geneticists have successfully searched for mutant alleles that prevent the normal process of embryonic development. In many cases, the offspring die at early embryonic or larval stages. These are called maternal effect lethal alleles. How would a researcher identify a mutation that produced a recessive maternal effect lethal allele?arrow_forward
- Why does a loss or an excess in genetic material lead to the expression of an abnormal phenotype?arrow_forwardSuppose a maternal effect gene exists as a functional dominant allele and a nonfunctional recessive allele. A mother with the disorder produces all offspring without the disorder. Explain the genotype of the mother.arrow_forwardMaternal influence is considered a transient inheritance, explain?arrow_forward
- In humans, hemophilia is an X-linked recessive gene and will only be expressed in females if they are homozygous for this gene. However, in some rare cases, a heterozygote becomes hemophilic. Explain how this incident happens.arrow_forwardWhy a loss or an excess in genetic material leads to the expression of an abnormal phenotype?arrow_forwardPlease explain how the deletion of the same set of genes can result in such different diseases. The example for this question being Prader-willi syndrom and Angelman syndrome. In your answer, be sure to discuss the role of genetic imprinting and epigenetics.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY