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Chapter 8, Problem 21BO

(a)

Summary Introduction

To determine: The sugar-phosphate backbone for each strand of DNA duplex of HIV-1 along with identification of 5 end of each strand, location of major and minor grooves, and whether the helix is left or right-handed.

Introduction:

A DNA occurs in three types of conformation: A, B and Z-forms. These forms are found under different physiological conditions and have characteristic sequences of bases which differentiate them from each other. The study of three-dimensional sructure of DNA helped researchers to gain information about about how DNA conveys information which is passed from one generation to another.

(b)

Summary Introduction

To determine: Whether the Z conformation helix is left or right-handed is to be determined.

Introduction:

A DNA occurs in three types of conformation: A, B and Z-forms. These forms are found under different physiological conditions and have characteristic sequences of bases which differentiate them from each other. The study of three-dimensional sructure of DNA helped researchers to gain information about about how DNA conveys information which is passed from one generation to another.

(c)

Summary Introduction

To determine: The tips for successful three-dimensional structure viewing.

Introduction:

A DNA occurs in three types of conformation: A, B and Z-forms. These forms are found under different physiological conditions and have characteristic sequences of bases which differentiate them from each other. The study of three-dimensional sructure of DNA helped researchers to gain information about about how DNA conveys information which is passed from one generation to another.

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