WHAT IS LIFE? A GUIDE TO BIO W/PHYSIO
20th Edition
ISBN: 9781319421670
Author: PHELAN
Publisher: MAC HIGHER
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Chapter 6, Problem 8MC
Summary Introduction
Introduction:
Mutations can be of three types – additions, deletions and substitution.
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Which type of mutation would expect would have no effect on a protein coding gene in eukaryotes?
a.a single base substitution that creates a splice site mutation
b.a single base substitution that creates a synonymous mutation
c.a single base deletion that creates a frameshift near the 3' end of the open reading frame
d.a single base substitution that creates a non-conservative missense mutation
e.a single base substitution that creates a conservative missense mutation
Could a frameshift mutation result in the production of a larger than wild type protein?
A.Yes, but it’s likely only if the frameshift occurs early in the coding sequence.
B.Yes, but it’s likely only if the frameshift occurs late in the coding sequence.
C.Yes, by producing a longer than normal transcript
D.Yes, by producing larger than normal Okazaki fragments.
E.No, frameshift always results in the occurrence of STOP codons and premature termination of translation
Why might a single base-pair mutation in eukaryotic mRNA be less serious than one in prokaryotic mRNA?
a. If the mutation occurs in the 5' end of the start site, it will not affect the gene product.
b. If the mutation occurs in the exon, it will not affect the gene product.
c. If the mutation occurs in the splice site of a transcript with alternative splicing, only one gene product may
affected.
O d. If the mutation occurs in the intron or not in the splice site of a transcript with alternative splicing, it will nc
affect the gene product.
O e. If the mutation occurs in the 3' end of the start site, it will not affect the gene product.
OLIE STIC N 1A
Chapter 6 Solutions
WHAT IS LIFE? A GUIDE TO BIO W/PHYSIO
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following mutations would have the greatest negative impact on the protein product of a gene? A. a single base deletion close to the end of the coding region of a gene. B. a single base insertion near the start of the coding region of the gene C. a base-pair substitution D. a deletion of three bases near the middle of the genearrow_forwardThere are 61 mRNA codons that specify an amino acid, but only 45 tRNAs. This is best explained by the fact that A. some tRNAs have anticodons that recognize two or more different codons. B. the rules for base pairing between the third base of a codon and tRNA are flexible. C. many codons are never used, so the tRNAs that recognize them are dispensable. D. A and B only E. A, B, and Carrow_forwardIf a mutation deletes the promoter in a eukrayotic gene, which of the following most accurately describes its consequence? A. There will be no mRNA or polypeptide made. B. The mRNA will be made but no polypeptide is made. C. The mRNA will not be processed properly. D. Nothing will happen. It is a silent mutation.arrow_forward
- Which of the following would probably cause the most severe damage to a gene's expression and phenotype a. A missense mutation changing the first methionine codon to an arginine codon. b. A deletion of a base in the 455th codon of a 456-amino acid protein. c. Alteration of a UGG codon to a UGA codon at position 324 of a 324 amino acid protein. d. Mutation of a GUC codon (valine) to a GUU codon (valine).arrow_forwardA geneticist induces a mutation in eukaryote cells. The mutation results in an inability to form the poly(A) tail during processing of pre-mRNA. What does this mean for the mature mRNA and what will be the effect on these cells? Possible Answers: A. The mRNA will be spliced, but will not have a 5' cap. B. The mRNA will likely be degraded. C. The mRNA will not be cleaved. D. The mRNA will have too many Gs and Cs.arrow_forwardWhich of the following statements about RNA processing in eukaryotes is INCORRECT? A. The excision of introns from pre-mRNA is the only modification required to produce a mature mRNA. B. A protein/RNA complex is used to remove introns from the pre-mRNA. C. A poly A tail is added on to the 3′ end of the mRNA. D. A 7-methylguanosine cap is added on to the 5′end of the mRNA. E. Modification occurs in the nucleus.arrow_forward
- Explain point mutations and frameshift mutations. Which is more apt to disrupt the structure and or function of a protein coded for by a gene? Why?arrow_forwardThe original DNA base sequence is 5’-AGCGTTACCGT-3’; a mutation in the DNA strand results in the base sequence 5’-AGGCGTTACCGT-3’. What can you conclude about the mutation? A. It is a frameshift mutation. B. It is a silent mutation. C. It is a deleterious mutation. D. It may result in a single amino acid change in the protein being coded for by this base sequence.arrow_forwardA genetic researcher notices that individuals with a particular genetic disease have a shortened version of key protein involved in the diseased biochemical pathway. Which of the following mutations is most likely to result in the premature termination of protein synthesis? A. The disease is caused by a silent mutation. B. The disease is caused by a frameshift mutation. C. The disease is caused by a missense mutation. D. The disease is caused by a nonsense mutation.arrow_forward
- Arrange the statements in their proper order by writing the corresponding letter (e.g. A) for each statement in the space provided below. A. The single-stranded RNA would complement the target RNA. B. Gene expression is inactivated once the mRNA is no longer accessible for translation. C. The risk-induced silencing complex which is composed of RNA and protein subunits is formed. D. Double-stranded, non-coding RNA is cleaved by Dicer. E. The mRNA can be cleaved or remain bound by the RISC. 1. 2. 3. 4. 5.arrow_forwardWhich of the following mutations is most likely to cause a single amino acid difference during the translation of mRNA into protein? A. Single base-pair insertion B. Single base-pair deletion C. Mutations in regulatory sites D. Base-pair substitutionarrow_forwardA SNV mutation that results in no change in the amino acid sequence is called: A. silent mutation B. silencing mutation C. missense mutation D. nonsense mutation E. frameshift mutationarrow_forward
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