Campbell Biology in Focus
3rd Edition
ISBN: 9780134710679
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Rebecca Orr
Publisher: PEARSON
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Textbook Question
Chapter 5.6, Problem 1CC
During an epinephrine-initiated signal in liver cells, in which of the three stages of cell signaling does glycogen phosphorylase act?
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During the epinephrine signaling pathway we learned about in class, the enzyme glycogen phosphorylase is regulated by:
Allosteric regulation
Covalent modification
Competitive inhibition
Zymogen activation
In liver cells, glycogen phosphorylase acts in which of the three stages of the signaling pathway associated with an epinephrine-initiated signal?
Given what we know about epinephrine and glucose 6-phosphate dehydrogenase, would you predict that glucose 6-dehydrogenase is activated, inhibited, or unaffected by epinephrine induced cell signaling? Explain your prediction.
Chapter 5 Solutions
Campbell Biology in Focus
Ch. 5.1 - Plasma membrane proteins have carbohydrates...Ch. 5.1 - WHAT IF? How would the membrane lipid composition...Ch. 5.2 - What property allows O2 and CO2, to cross a lipid...Ch. 5.2 - Why is a transport protein needed to move many...Ch. 5.2 - MAKE CONNECTIONS Aquaporins exclude passage of...Ch. 5.3 - How do you think a cell performing cellular...Ch. 5.3 - WHAT IF? If a Paramecium caudatum cell swims from...Ch. 5.4 - Sodium-potassium pumps help nerve cells establish...Ch. 5.4 - Prob. 2CCCh. 5.4 - MAKE CONNECTIONS Review the characteristics of the...
Ch. 5.5 - As a cell grows, its plasma membrane expands. Does...Ch. 5.5 - Prob. 2CCCh. 5.5 - MAKE CONNECTIONS In Concept 4.7, you learned that...Ch. 5.6 - During an epinephrine-initiated signal in liver...Ch. 5.6 - When a signal transduction pathway involves a...Ch. 5.6 - WHAT IF? How can a target cells response to a...Ch. 5 - In what way do the membranes of a eukaryotic cell...Ch. 5 - Which of the following factors would tend to...Ch. 5 - Phosphorylation cascades involving a series of...Ch. 5 - Lipid-soluble signaling molecules, such as...Ch. 5 - Which of the following processes includes all the...Ch. 5 - Based on Figure 5.17.which of these experimental...Ch. 5 - Prob. 7TYUCh. 5 - SCIENCE, TECHNOLOGY, AND SOCIETY Extensive...Ch. 5 - FOCUS ON EVOLUTION Paramecium and other...Ch. 5 - FOCUS ON INTERACTIONS A human pancreatic cell...Ch. 5 - SYNTHESIZE YOUR KNOWLEDGE In the supermarket,...
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- What are the three main parts of a signaling pathway? Give a detailed specific example, such as how epinephrine signals for rapid digestion of glycogen in liver cells.arrow_forward(a) Predict the effect of a mutation that enhances the activity of the kinase associated with the PDH complex. (b) Predict the effect of a mutation that reduces the activity of the phosphatase associated with the PDH complex.arrow_forwardA mutated form of the α subunit of the heterotrimeric G protein has been identified; this form readily exchanges nucleotides even in the absence of an activated receptor. What would be the effect on a signaling pathway containing the mutated α subunit?arrow_forward
- Nerve-growth factor (NGF) binds to a protein tyrosine kinase receptor. The amount of diacylglycerol in the plasma membrane increases in cells expressing this receptor when treated with NGF. Propose a simple signaling pathway and identify the isoform of any participating enzymes. Would you expect the concentrations of any other common second messengers to increase on NGF treatment?arrow_forwardSuppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a receptor. How might this mutation affect signaling involving a GPCR? Which subunit of the G protein is most likely affected by the mutation?arrow_forwardDescribe the events required for full activation of protein kinase B. Name two effects of insulin mediated by PKB in muscle cells.arrow_forward
- In some forms of diabetes, a mutation in the b subunit of the insulin receptor abolishes the enzymatic activity of that subunit. How does the mutation affect the cell’s response to insulin? Can additional insulin (e.g., from injections) overcome the defect?arrow_forward1) the Ga subunit has a mutation resulting in increased GTPase activity? Why is the GPCR referred to as a GEF? What would occur in G protein signalling ifarrow_forwardWhich step of cell signaling is exemplified by the section called "Phosphorylation cascade"?arrow_forward
- A cellular response occurs when a signal transduction pathway is activated in animals. Explain two forms of cellular responses that may arise as a result of paracrine or endocrine signaling.arrow_forwardDescribe the function of the PTEN phosphatase in the PI-3 kinase signaling pathway. Why does a loss-of-function mutation in PTEN promote cancer? Predict the effect of constitutively active PTEN on cell growth and survival.arrow_forwardDescribe the mechanisms that limit signaling by the phosphoinositide pathway.arrow_forward
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