Campbell Biology (11th Edition)
Campbell Biology (11th Edition)
11th Edition
ISBN: 9780134093413
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Chapter 47.3, Problem 4CC
Summary Introduction

To explain: The expected result, when zone of polarizing activity (ZPA) is removed from a limb bud and then a bead dripped in sonic hedgehog is placed in the center of the limb bud.

Concept introduction: The limb bud development is determined by two regions – the apical ectodermal ridge (AER) and the zone of polarizing activity (ZPA). The AER region determines the growth of a limb along the proximal-distal axis. The ZPA region determines the growth of the limb along the anterior-posterior axis.

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