Lycopene, which is abundant in tomatoes, is thought to have a potential benefit in protecting against many types of cancers. In the study, the results of which are shown in the Figure, mice were exposed to tobacco smoke or normal air. The amount of lung tissue damage caused by each exposure was measured in mice that were given tomato juice (1) or water (2). To estimate the destruction of the alveolar wall, a destructive index (DI) was calculated from histological slides of the lung. All lungs will show some level of damage, but a DI above 10% is considered significant destruction.
What is the effect of tobacco smoke on the lung tissue in these mice?
Source: Based on S. Kasagi et al. 2006. Tomato juice prevents senescence-accelerated mouse P1 strain from developing emphysema induced by chronic exposure to tobacco smoke. American Journal of Physiology–Lung Cellular and Molecular Physiology 290:L396–L404.
Want to see the full answer?
Check out a sample textbook solutionChapter 46 Solutions
Biology: The Dynamic Science (MindTap Course List)
- In a study of O2 uptake by muscle at high altitude, a physiologist prepares an atmosphere consisting of 79 mole % N2, 17 mole % 16O2, and 4.0 mole % 18O2. (The isotope 18O will be measured to determine O2 uptake.) The total pressure is 0.75 atm to simulate high altitude. Calculate the mole fraction and partial pressure of 18O2 in the mixture.arrow_forwardSupernumerary fusion cells (FCs) form in the dorsal trunk (DT) in aopO199 embryonic trachea. How could you test whether the extra FCs are from FCs dividing, or from a change in the fate of other tracheal cells? What other possible cellular mechanism could be taking place here?arrow_forwardThe time it takes for blood to pass through the capillaries of a pulmonary alveolus typically is less than 0.3 seconds. During this time, what will occur? Select one: a. The blood plasma will be cleansed of its entire CO2 content and will be saturated with O2. b. An enzyme will catalyze the conversion of oxyhemoglobin to carboaminohemoglobin. c. Blood will pick up CO2 and O2 will be released to the alveolus. d. Blood will pick up O2 and CO2 will be released to the alveolus.I think this is C or D tell me the answer and whyarrow_forward
- After spending a day or more at high altitude (with an oxygen partial pressure of 75 torr), the concentration of 2,3- bisphosphoglycerate (2,3-BPG) in red blood cells increases. What effect would an increased concentration of 2,3-BPG have on the oxygen-binding curve for hemoglobin? Why would this adaptation be beneficial for functioning well at high altitude?arrow_forwardCOVID-19 symptoms are assiociated with which of the following pathology? a. Alveolar destruction b. Impaired gas exchange c. Mucus production d. Fluid accumulation in the alveolus e. All of the abovearrow_forwardYou are studying with a friend who is describing the Bohr effect. She tells you that in the lungs, hemoglobin binds oxygen and releases hydrogen ion; as a result, the pH increases. She goes on to say that in actively metabolizing muscle tissue, hemoglobin releases oxygen and binds hydrogen ion and, as a result, the pH decreases. Do you agree with her reasoning? Why or why not?arrow_forward
- ㅂ 분 20 4 3 2 U Bronchoalveolar lavage fluid obtained from a 34-year-old healthy volunteer is found to contain elastase. The enzyme is most likely derived from which of the following cells? A. Type I pneumocytes B. Type Il pneumocytes C. Clara cells D. Alveolar macrophages E. Goblet cells F. Ciliated epitheliumarrow_forwardIn addition to O2 binding, changes in other chemical conditions can result in changes in hemoglobin structure and function. Increases in blood H+ result in oxygen binding curves for hemoglobin that are shifted to the right. The effect of H+ can be understood in terms of the equilibrium:H-Hb+ + O2 → Hb-O2 + H+How does the difference in pH in the lungs and tissues help hemoglobin do its job of delivering oxygen? Use the equilibrium equation in your argument.arrow_forwardThe alveoli and blood capillaries make up the gas exchange surface of the lungs, and as the arrows in the diagram (Figure 3) illustrate, this is where oxygen and carbon dioxide move in a particular direction. a) With reference to simple diffusion, explain why oxygen and carbon dioxide move in the directions illustrated by the arrows. b) The gas exchange surface is specifically adapted to maximise the transport of oxygen and carbon dioxide in these illustrated directions. Explain at least three of these adaptations.arrow_forward
- (b) The diagram on the right compares O2-dissoci- ation curves for human hemoglobins characterized by dif- ferent p50 values. If Ko2 represents the equilibrium disso- ciation constant for oxygen binding, e.g., Hb(02)n Hb + nO₂ show the relationship between Ko2 and p50. Assign one of the curves (a, b, e) that best approxi- mates the Ko2 of each of the mutant hemoglobins in the table above including HbA where Ko2 represents the equi- librium dissociation constant for oxygen binding. If no curve is present for any of the mutant hemogobins, state the rea- son why the mutant is not represented. Indicate on the graph where its p50 would lie. PERCENT SATURATION 100- 80- 60- 40- 20- PARTIAL PRESSURE OF OXYGEN lungs veins muscle 0- 0 20 bc/d T 100 120 140 40 60 80 OXYGEN PRESSURE (millimeters of mercury) (c) Of the mutant hemoglobins in the table above, which form a hydrogen bond stabilizing the R (oxy) conformation similarly to that in wild type HbA. Justify this statement on the basis of the…arrow_forwardWhich of the following does not happen at the O₂ binding site of hemoglobin (Hb)? 1) Movement of the metal co-factor II) Protonation of the proximal His III) The spin state change of the Fe2+ ion IV) Change of shape of the protoporphyrin IX ring OI ON O III Ollarrow_forwardOxygen affinity of fetal blood is higher than that of maternal blood and may help to provide the fetus with an adequate oxygen supply during pregnancy. In mammals, 2, 3-biphosphosphoglycerate (BPG) mediates intracellular hemoglobin function by lowering cxygen affinity. Fetal red blood cells have higher affinity for oxygen because of a smaller effect of BPG on oxygen affinity of fetal hemoglobin (Hb F) compared with adult Hb (Hb A). Which symbol shows the PS0 value corresponding to Hb F? 14 12 10 0.0 0.5 1.0 1.5 2.0 2,3-BPG (mM) O Crcle O Dimond O Square O Triangle (6H ww) darrow_forward
- Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning