To determine:
The hypothetical drug that blocked the receptors for FSH and LH would be useful in men.
Introduction:
The follicle-stimulating hormone (FSH) and luteinizing hormones (LH) are the gonadotropin hormones that are secreted by the anterior lobe of the pituitary gland. They regulate and control the development, puberty, growth, and reproductive events of the body. In both females and males, the FSH and LH stimulate the maturation of the primordial germ cells.
Explanation of Solution
Yes, a hypothetical drug that blocked the receptors for FSH and LH would be useful in males. In human males, the sexual maturation or puberty is marked by the release of Gonadotropin-Releasing Hormone (GnRH) secreted from the hypothalamus. The GnRH triggers the secretion of the LH and FSH from the anterior lobe of the pituitary gland. LH incites the Leydig cells to produce the testosterone, and FSH that works with testosterone to incite spermatogenesis (sperm formation).
So, if a hypothetical drug blocks the receptor for FSH and LH, it will reduce the production of testosterone and the spermatogenesis, which in turn may be used as a potent contraceptive method.
To determine:
The mechanism of action of a hypothetical drug that blocked the receptors for FSH and LH.
Introduction:
FSH receptors are found on the surface of the Sertoli cells and spermatogonia whereas, the LH receptors are found only on the Leydig cells. The activation of the LH receptors stimulates the production of the androgen hormone. The activation of the FSH receptors stimulates the Sertoli cells to produce the testosterone hormone.
Explanation of Solution
The mechanism of action of a drug that blocked the FSH and LH receptor, can be explained by drug-receptor binding mechanism. Drug-receptor binding involves several types of bonds such as ionic, hydrogen, covalent and Van Der Waals force. So, a drug that blocked the receptors of the FSH and LH, will result in the blocking of the sperm formation and testosterone production.
To determine:
The side effects of a drug that blocked the FSH and LH receptors.
Introduction:
The follicle-stimulating hormone (FSH) and luteinizing hormones (LH) are the gonadotropin hormones that are secreted by the anterior lobe of the pituitary gland. FSH receptors are found on the surface of the Sertoli cells and spermatogonia. Whereas, the LH receptors are found only on the Leydig cells.
Explanation of Solution
The side effects of the drug that blocked the FSH and LH receptors are.
The reduction in testosterone would have a feminizing influence on the male body and male libido.
Sexual desire and performance would be greatly reduced.
Hence, if a hypothetical drug blocked the receptor for FSH and LH, it will reduce the production of testosterone and the spermatogenesis. This approach may be used as a potent contraceptive method but it will greatly reduced the sexual desire and performance.
Want to see more full solutions like this?
Chapter 42 Solutions
Biology: Life on Earth with Physiology (11th Edition)
- Match each hormone with its effect. oxytocin a. growth of facial hair testosterone b. uterus contracts LH c. LH, FSH are released GnRH d. surge causes ovulation FSH e. follicle develops HCG f. milk is produced prolactin g. corpus luteum is maintainedarrow_forwardMatch the hormones to the organ that makes them or to the action they cause. Use letters more than once. A. estrogen B. follicle stimulating hormone (FSH) C. human chorionic gonadotropin (HCG) D. luteinizing hormone (LH) E. progesterone F. testosterone v blastula v corpus luteum Leydig's cells A. A ovary v 1st hormone of pituitary gland to start cycle В. В С.С 2nd hormone of pituitary gland halfway through cycle D. D vendometrium grows more blood vessels Е. E v keeps corpus luteum v stimulates sperm production, muscle growth, aggression F. F v keeps endometrium in uterus ovulation (egg leaves ovary) v tells egg to developarrow_forwardCombined oral contraceptives are composed of synthetic estrogen combined with small amounts of synthetic progesterone. Your client, Mrs. Vanessa Narciso, has been using COCs as her primary contraception method. She comes to the clinic complaining "Bakit hindi pa din ako mabuntis? Tumigil na naman ako ng paginom ng pills.". Your most appropriate response will be: "You should talk to your doctor immediately. You might have developed complications from prolonged use of the pill Your body just needs time to recover from the effects of the pill It may be difficult to get pregnant during the first 3 to 12 months after discontinuation. "It is best not to try to get pregnant at this time since your intake of COCs may cause birth defects "You should have been able to conceive by now. Would your husband be willing to undergo labsly testarrow_forward
- E B A В Identify the structure that secretes the hormone involved in the development of the secondary male sex characteristics and contributes to spermatogenesis. Select one: a. D, which is the Sertoli cell b. A, which is the spermatocyte O c. C, which is the sperm cell O d. B, which is the interstitial cellarrow_forwardFSH stimulates cells to secrete Androgen Binding Protein. OA. Interstitial O B. Leydig O C. Sustentacular cells O D. Spermarrow_forward1. Ella accidentally ingests the poison tetrodotoxin from the pufferfish, which you know blocks voltage-gated Na+ channels. Predict the symptoms Albert will experience from this poisoning. 2. What type of sexual dysfunction might arise in men taking drugs that inhibit sympathetic nervous system activity as part of the treatment for high blood pressure? 3(b). How might the female orgasm increase the chance for fertilization to occur? 4(c). Explain why oral contraceptives, which artificially raise levels of estrogens and progesterone, prevent pregnancy.arrow_forward
- Which of the oral contraceptives listed below has anti-androgen properties?A. MersolonB. NovinetC. LindynetD. LogestE. Diane 35arrow_forwardBased on the schematic below, illustrating the control of the hypothalamus and the pituitary gland by the ovarian hormones, how would you design a hormonal female contraceptive that keeps secretion of FSH and LH low in order to prevent ovulation?arrow_forwardEnumerate at least nine (9) physiologic actions of estrogenarrow_forward
- Which of the following statement correctly describe the role of androgen in the male reproductive system? Select one: A. LH stimulates the Sertoli cell to produce inhibin and to start spermatogenesis. B. Increased levels of inhibin released by the interstitial cells result in lower levels of FSH and testosterone. C. Increased levels of testosterone feedbacks negatively to the anterior pituitary and hypothalamus. D. GnRH is released by the anterior pituitary and stimulates the release of FSH and LH.arrow_forwardSuppose you want to produce a male birth control pill. On the basis ofwhat you know about the male hormone system, what process shouldthe pill affect? Discuss any possible side effects of the pillarrow_forwardExplain what the hormones LH and FSH does to the male and female body. What do each secrete? How does each affect the body?arrow_forward
- Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
- Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax CollegeHuman Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning