Understanding Pathophysiology, 6e
Understanding Pathophysiology, 6e
6th Edition
ISBN: 9780323354097
Author: Sue E. Huether RN PhD, Kathryn L. McCance RN PhD
Publisher: Elsevier Science
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Chapter 4.1, Problem 3QC
Summary Introduction

To explain: The mechanisms of ischemia-reperfusion injury.

Concept introduction: Ischemia-reperfusion injury is the cellular damage caused when the supply of blood returns to the cell after a session of ischemia. Cellular injury refers to the injury that occurs to the cells and to the extra cellular matrix (ECM). The cellular injury occurs when the cell is unable to maintain adaptive steady state during injurious stimuli. The deficiency of nutrients and oxygen from blood during the ischemic session makes a condition in which the restoration of blood circulation process leads to inflammation and oxidative damage during the oxidative stress induction with restoration of normal function.

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