Explanation The ionizable group of serine at neutral pH is an amino group and its ionization constant is pK 2 = 9 .21 . The ionizable group of histidine at neutral pH is a side chain and its ionization constant is pK R = 6.04 . Therefore, the isoelectric point (p I ) of dipeptide is as follows: p I = ( p K 2 + p K R Summary Introduction To explain: The reasons why the isoelectric point of a Ser-His dipeptide is only an estimate.

Fundamentals of Biochemistry: Life at the Molecular Level

5th Edition

ISBN: 9781118918401

Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt

Publisher: WILEY

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Question

Chapter 4, Problem 24CQ

Summary Introduction

To determine: .The isoelectric point of a Ser-His dipeptide.

Concept introduction: The isoelectric point is the pH at which net electric charge of a molecule is zero.

Summary Introduction

To explain: The reasons why the isoelectric point of a Ser-His dipeptide is only an estimate.

Expert Solution & Answer

Chapter 4 Solutions

Fundamentals of Biochemistry: Life at the Molecular Level

Ch. 4 - Prob. 1E Ch. 4 - 2. Glutamate, a 5-carbon amino acid, is the...Ch. 4 - Prob. 3E Ch. 4 - Prob. 4E Ch. 4 - 5. Draw the dipeptide Asp-His at pH 7.0. Ch. 4 - 6. Calculate the number of possible pentapeptides...Ch. 4 - 7. Identify the hydrogen bond donor and acceptor...Ch. 4 - 8. In some proteins, the side chain of serine...Ch. 4 - 9. Determine the net charge of the predominant...Ch. 4 - 10. Determine the net charge of the predominant...

Ch. 4 - Prob. 11E Ch. 4 - 12. Circle the chiral carbons in the following...Ch. 4 - Prob. 13E Ch. 4 - 14. Patients with Parkinson’s disease are...Ch. 4 - 15. Over time, the glutamine residues of...Ch. 4 - 16. Some hormone-signaling pathways result in the...Ch. 4 - 17. Which amino acids have side chains that are...Ch. 4 - 18. Draw the structure of Lys and Ala linked by an...Ch. 4 - 19. Some bacteria produce poly-?-glutamic acid, a...Ch. 4 - Prob. 20E Ch. 4 - 21. A sample of the amino acid tyrosine is barely...Ch. 4 - Prob. 22CQ Ch. 4 - 23. Calculate the pI of (a) Ala, (b) His, and (c)...Ch. 4 - Prob. 24CQ Ch. 4 - 25. Draw the peptide ATLDAK. (a) Calculate its...Ch. 4 - 26. The protein insulin consists of two...Ch. 4 - Prob. 27CQ Ch. 4 - 28. The two C?H atoms of Gly are said to be...Ch. 4 - Prob. 29CQ Ch. 4 - Prob. 30CQ Ch. 4 - 31. Identify the amino acid residue front which...Ch. 4 - Prob. 32CQ Ch. 4 - Prob. 33CQ Ch. 4 - Prob. 34CQ Ch. 4 - Prob. 1MTE

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