Biology
12th Edition
ISBN: 9780078024269
Author: Sylvia Mader, Michael Windelspecht
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 36, Problem 2TS
The renin-angiotensin-aldosterone system can be inhibited in order to reduce high blood pressure. Usually, the angiotensin-converting enzyme, which converts angiotensin I to angiotensin II, is inhibited by drug therapy. Why would this enzyme be an effective point which to disrupt the system?
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A patient you are monitoring has been on Telmisartan (Cozaar), an angiotensin receptor blocker for managing their hypertension. The drug must be metabolized by CYP2C9 or CYP3A4 from a 5-methanol to a 5-carboxylic acid to exhibit its effects. After 2 years of successful therapy, their blood pressure suddenly increases. Why might this occur, and what would you suggest as a substitute?
Drugs that directly act on the Renin-Angiotensin-Aldosterone (RAA) system may be
used to treat hypertension. Drugs that affect this system include all of the following,
except?
O 1) Enalapril (Vasotec)
2) Valsartan [Diovan]
3) Carvedilol (Coreg)
O 4) Spironalactone (Aldactone]
Describe in detail the renin-angiotensinogen pathway
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