Building Better Bones Tiffany, shown in FIGURE 35.22, was born with multiple fractures in her arms and legs. By age six, she had undergone surgery to correct more than 200 bone fractures. Her fragile, easily broken bones are symptoms of osteogenesis imperfecta (OI), a genetic disorder caused by a mutation in a gene for collagen. As bones develop, collagen forms a scaffold for deposition of mineralized bone tissue. The scaffold forms improperly in children with OI. FIGURE 35.22 also shows the results of a test of a new drug. Treated children, all less than two years old, were compared to similarly affected children of the same age who were not treated with the drug.
Vertebral | |||
Treated | area in cm2 | Fractures | |
child | (Initial) | (Final) | per year |
1 | 14.7 | 16.7 | 1 |
2 | 15.5 | 16.9 | 1 |
3 | 6.7 | 16.5 | 6 |
4 | 7.3 | 11.8 | 0 |
5 | 13.6 | 14.6 | 6 |
6 | 9.3 | 15.6 | 1 |
7 | 15.3 | 15.9 | 0 |
8 | 9.9 | 13.0 | 4 |
9 | 10.5 | 13.4 | 4 |
Mean | 11.4 | 14.9 | 2.6 |
Vertebral | |||
Treated | area in cm2 | Fractures | |
child | (Initial) | (Final) | per year |
1 | 18.2 | 13.7 | 4 |
2 | 16.5 | 12.9 | 7 |
3 | 16.4 | 11.3 | 8 |
4 | 13.5 | 7.7 | 5 |
5 | 16.2 | 16.1 | 8 |
6 | 18.9 | 17.0 | 6 |
Mean | 16.6 | 13.1 | 6.3 |
FIGURE 35.22 Results of a clinical trial of a drug treatment for osteogenesis imperfecta (OI), which affects the child shown at right. Nine children with OI received the drug. Six others were untreated controls. Surface area of certain vertebrae was measured before and after treatment. Fractures occurring during the 12 months of the trial were also recorded.
2. How many of the untreated children showed an increase in vertebral area?
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Chapter 35 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
- The cell found in bone that makes the bone is called an. osteoblast osteocyte osteoclast osteonarrow_forwardWhy are osteocytes spread out in bone tissue? They develop from mesenchymal cells. They are surrounded by osteoid. They travel through the capillaries. Formation of osteoid spreads out the osteoblasts that fanned the ossification centers.arrow_forwardThe cell found in bone that breaks it down is called an. osteoblast osteocyte osteoclast osteonarrow_forward
- Building Better Bones Tiffany, shown in FIGURE 35.22, was born with multiple fractures in her arms and legs. By age six, she had undergone surgery to correct more than 200 bone fractures. Her fragile, easily broken bones are symptoms of osteogenesis imperfecta (OI), a genetic disorder caused by a mutation in a gene for collagen. As bones develop, collagen forms a scaffold for deposition of mineralized bone tissue. The scaffold forms improperly in children with OI. FIGURE 35.22 also shows the results of a test of a new drug. Treated children, all less than two years old, were compared to similarly affected children of the same age who were not treated with the drug. Vertebral Treated area in cm2 Fractures child (Initial) (Final) per year 1 14.7 16.7 1 2 15.5 16.9 1 3 6.7 16.5 6 4 7.3 11.8 0 5 13.6 14.6 6 6 9.3 15.6 1 7 15.3 15.9 0 8 9.9 13.0 4 9 10.5 13.4 4 Mean 11.4 14.9 2.6 Vertebral Treated area in cm2 Fractures child (Initial) (Final) per year 1 18.2 13.7 4 2 16.5 12.9 7 3 16.4 11.3 8 4 13.5 7.7 5 5 16.2 16.1 8 6 18.9 17.0 6 Mean 16.6 13.1 6.3 FIGURE 35.22 Results of a clinical trial of a drug treatment for osteogenesis imperfecta (OI), which affects the child shown at right. Nine children with OI received the drug. Six others were untreated controls. Surface area of certain vertebrae was measured before and after treatment. Fractures occurring during the 12 months of the trial were also recorded. 3. How did the rate of fractures in the two groups compare?arrow_forwardBuilding Better Bones Tiffany, shown in FIGURE 35.22, was born with multiple fractures in her arms and legs. By age six, she had undergone surgery to correct more than 200 bone fractures. Her fragile, easily broken bones are symptoms of osteogenesis imperfecta (OI), a genetic disorder caused by a mutation in a gene for collagen. As bones develop, collagen forms a scaffold for deposition of mineralized bone tissue. The scaffold forms improperly in children with OI. FIGURE 35.22 also shows the results of a test of a new drug. Treated children, all less than two years old, were compared to similarly affected children of the same age who were not treated with the drug. Vertebral Treated area in cm2 Fractures child (Initial) (Final) per year 1 14.7 16.7 1 2 15.5 16.9 1 3 6.7 16.5 6 4 7.3 11.8 0 5 13.6 14.6 6 6 9.3 15.6 1 7 15.3 15.9 0 8 9.9 13.0 4 9 10.5 13.4 4 Mean 11.4 14.9 2.6 Vertebral Treated area in cm2 Fractures child (Initial) (Final) per year 1 18.2 13.7 4 2 16.5 12.9 7 3 16.4 11.3 8 4 13.5 7.7 5 5 16.2 16.1 8 6 18.9 17.0 6 Mean 16.6 13.1 6.3 FIGURE 35.22 Results of a clinical trial of a drug treatment for osteogenesis imperfecta (OI), which affects the child shown at right. Nine children with OI received the drug. Six others were untreated controls. Surface area of certain vertebrae was measured before and after treatment. Fractures occurring during the 12 months of the trial were also recorded. 4. Do these results shown support the hypothesis that this drug, which slows bone breakdown, can increase bone growth and reduce fractures in young children with OI?arrow_forwardBuilding Better Bones Tiffany, shown in FIGURE 35.22, was born with multiple fractures in her arms and legs. By age six, she had undergone surgery to correct more than 200 bone fractures. Her fragile, easily broken bones are symptoms of osteogenesis imperfecta (OI), a genetic disorder caused by a mutation in a gene for collagen. As bones develop, collagen forms a scaffold for deposition of mineralized bone tissue. The scaffold forms improperly in children with OI. FIGURE 35.22 also shows the results of a test of a new drug. Treated children, all less than two years old, were compared to similarly affected children of the same age who were not treated with the drug. Vertebral Treated area in cm2 Fractures child (Initial) (Final) per year 1 14.7 16.7 1 2 15.5 16.9 1 3 6.7 16.5 6 4 7.3 11.8 0 5 13.6 14.6 6 6 9.3 15.6 1 7 15.3 15.9 0 8 9.9 13.0 4 9 10.5 13.4 4 Mean 11.4 14.9 2.6 Vertebral Treated area in cm2 Fractures child (Initial) (Final) per year 1 18.2 13.7 4 2 16.5 12.9 7 3 16.4 11.3 8 4 13.5 7.7 5 5 16.2 16.1 8 6 18.9 17.0 6 Mean 16.6 13.1 6.3 FIGURE 35.22 Results of a clinical trial of a drug treatment for osteogenesis imperfecta (OI), which affects the child shown at right. Nine children with OI received the drug. Six others were untreated controls. Surface area of certain vertebrae was measured before and after treatment. Fractures occurring during the 12 months of the trial were also recorded. 1. An increase in vertebral area during the 12-month period of the study indicates bone growth. How many of the treated children showed such an increase?arrow_forward
- Why is cartilage slow to heal? because it eventually develops into bone because it is semi-solid and flexible because it does not have a blood supply because endochondral ossification replaces all cartilage with bonearrow_forwardThe cells responsible for bone resorption are ___________ . osteoclasts osteoblasts fibroblasts osteocytesarrow_forwardPart A. A race between two runners is often used as an analogy to describe the mechanism of endochondral ossification. Review endochondral ossification. In endochondral ossification, who are the two runners? Did each runner begin the race at the same time? Who is in the lead? How does the race end?arrow_forward
- Describe the biochemical defect that results in osteogenesis imperfecta.arrow_forwardDiscuss the stress-strain relationship on bone. In your discussion, include a graph of the stress-strain curve.arrow_forwardMany human bones grow by endochondral ossification. Describe how this process happens in a long bone like the femur and name the cells, structures and hormone(s) involved?arrow_forward
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