Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 27, Problem 28CQ
Summary Introduction

To check: Whether the mechanistic embellishment is consistent in tetrahedral intermediate with the observed pH effect in the residue A2486.

Concept introduction: The formation of the peptide bond is catalysed by the peptidyl transferase enzyme in the larger subunit of the ribosomes. The bond between the double-bonded carbon atoms that are transformed from the trigonal to tetrahedral forms a reaction intermediate called the tetrahedral intermediate.

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