Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 26, Problem 15P
In eukaryotic transcription, what is the function of a histone chaperone? Of a chromatin remodeling complex? Of Mediator?
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Which is the expected outcome following the deacetylation of histones?
a) Coiling of chromatin, preventing it from being accessed by transcriptional machinery
b) Coiling of chromatin, allowing it to be accessed by transcriptional machinery
c) Uncoiling of chromatin, preventing it from being accessed by transcriptional machinery
d) Uncoiling of chromatin, allowing it to be accessed by transcriptional machinery
What is the role of chromatin modification in transcription?
Typically, increased acetylation and decreased methylation of histone N-terminal tails in nucleosomes leads to
removal of the protein components of the chromatin from the DNA
relaxed packaging of the chromatin and increased transcription
increased amounts of euchromatin relative to heterochromatin
activation of topoisomerase
tighter packaging of the chromatin and reduced transcription
Chapter 26 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
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- What kind of changes Transcription Requires in Chromatin Structure and Nucleosome Position?arrow_forwardWhat are the transcription factors in eukaryotes? What is the role of transcription factors? What are the two types of transcription factors?arrow_forwardSince eukaryotic chromosomes are assembled with histone proteins, how are replication and transcription carried out? Describe the mechanisms.arrow_forward
- Explain the binding of transcription regulatory proteins to DNA ?arrow_forwardEuchromatin is said to be transcriptionally-active while Heterochromatin is said to be transcriptionally-inactive. What does this mean?arrow_forwardBriefly describe three stages of transcription. How is transcription initiated? How is transcription terminated?arrow_forward
- Where in the many steps of transcription initiation does regulation occur?arrow_forwardWhat are general transcription factors? When do you expect to find them? What is a cis acting regulatory sequence? Where are they located in comparison with the gene they are regulating?arrow_forwardHow many are the product(s) of transcription?arrow_forward
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