(a) Interpretation: The reason for the beneficial effects of ADP to ATP and AMP should be determined. Concept introduction: The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

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Answer 1

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

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Fo-F1 ATPase. The energy for ATP synthesis from ADP and Pi is provided by the downhill transport of protons through the rotary FoF1 ATP synthase . The enzyme has 3 alpha-beta and 12 ‘c’ subunits. The mitochondrion maintains change in membrane potential=180 mV (negative inside), pHin = 8, pHout=7, [Pi] = 3 mM and ADP is present as well. . What [ATP]/[ADP] ratio will be established at steady-state under these conditions? What would be the [ATP]/[ADP] ratio if the enzyme had only 9 ‘c’ subunits? full revolution of the crank (gamma subunit) produces 3 ATP.

Answer 2

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

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Answer 3

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

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Answer 4

Question

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

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Answer 5

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 6

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 7

Chapter 25, Problem 46P

Interpretation Introduction

(a)

Interpretation:

The reason for the beneficial effects of ADP to ATP and AMP should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The equilibrium constant for adenylate kinase is 1. The reason for this is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 10

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 11

Interpretation Introduction

(c)

Interpretation:

The reason for the facilitation of ATP synthesis due to AMP deamination, should be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 12

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 13

Interpretation Introduction

(d)

Interpretation:

The way by which ATP is synthesized aerobically due to the purine nucleotide cycle, is to be determined.

Concept introduction:

The purine nucleotide cycle is a metabolic process, in which aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine nucleotides. This cycle is comprised of three biochemical reactions, deamination of AMP to IMP, the formation of adenylosuccinate from IMP, and conversion of adenylosuccinate to AMP and fumarate.

Answer 14

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Answer 15

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Answer 16

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Answer 17

Ch. 25 - Prob. 1P Ch. 25 - Prob. 2P Ch. 25 - Prob. 3P Ch. 25 - Prob. 4P Ch. 25 - Prob. 5P Ch. 25 - Prob. 6P Ch. 25 - Prob. 7P Ch. 25 - Prob. 8P Ch. 25 - Prob. 9P Ch. 25 - Prob. 10P

Solution Summary: The author explains the purine nucleotide cycle, where aspartate and IMP are converted into ammonia and fumarate to regulate the levels of adenine.

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Chapter 25 Solutions