Biochemistry
6th Edition
ISBN: 9781337359573
Author: Reginald H. Garrett; Charles M. Grisham
Publisher: Cengage Learning US
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Textbook Question
Chapter 24, Problem 2P
Tracing Carbon Atom Incorporation in Fatty Acids (Integrates with Chapters 18 and 19.) Use the relationships shown in Figure 24.1 to determine which carbons of glucose will be incorporated into palmitic acid. Consider the cases of both citrate that is immediately exported to the cytosol following its synthesis and citrate that enters the TCA cycle.
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Consider the complete oxidation of a mixed TAG containing the following fatty acid residues:At carbon 1: cerotic acidAt carbon 2: heptadecanoic acidAt carbon 3: palmitoleic acid
Draw the structure of the mixed TAG.
During fatty acid biosynthesis, is it correct that the product detaches from fatty acid synthase complex when the chain length is 16 carbons?
In step 2 of the fatty acid biosynthesis, the acetyl-S-synthase condenses the acetyl group (C2)
with a malonyl-ACP (C3) and subsequent decarboxylation to acetoacetyl-ACP (C4). Give the
molecule [A] after condensation and before decarboxylation in the reaction below.
synthase
(A]
ACP + CO2
+ HS synthase
ACP
HO
S.
Chapter 24 Solutions
Biochemistry
Ch. 24 - Explaining the Stoichiometry of Fatty Acid...Ch. 24 - Tracing Carbon Atom Incorporation in Fatty Acids...Ch. 24 - Modeling the Regulation of AcetyI-CoA Carboxylase...Ch. 24 - Prob. 4PCh. 24 - Prob. 5PCh. 24 - Prob. 6PCh. 24 - Understanding the Stoichiometry of Cholesterol...Ch. 24 - Prob. 8PCh. 24 - Prob. 9PCh. 24 - Prob. 10P
Ch. 24 - Prob. 11PCh. 24 - Understanding the Mechanism of the...Ch. 24 - Prob. 13PCh. 24 - Understanding the Mechanism of the HMC-CoA...Ch. 24 - Prob. 15PCh. 24 - Prob. 16PCh. 24 - Prob. 17PCh. 24 - Prob. 18PCh. 24 - Prob. 19PCh. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
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- Looking at the structure of alpha linolenic acid, how many rounds of beta oxidation will occur to fully oxidize the fatty acid into acetyl CoA molecules? Please provide explanationsarrow_forwardThe second high energy intermediate metabolite of glycolysis that can be used for substrate level phosphorylation is also a precursor molecule for the synthesis of several amino acids. Name 5 of these amino acids.arrow_forwardIn the first cycle of fatty acid synthesis via the acyl carrier protein system, the acetyl group on fatty acid synthase condenses with the malonyl-ACP complex. Draw the structure of the products of this reaction. Respresent ACP by R1 do not include free synthase Be sure to include charges on atoms at Ph=7arrow_forward
- Explain why step 1 of the citric acid cycle is inhibited by succinyl-CoA. Be complete for full credit.arrow_forwardCompare between the Kreb cycle and fatty acid synthesis pathways in term of: 1. The type of metabolic pathway (catabolic or anabolic). 2. The reducing or oxidizing coenzymes needed for these pathways 3. Location of these pathways inside the cell. 4. Fate of acetyl CoA in both pathwaysarrow_forwardTriglyceride is an important energy reserve material for human body. When sugar supply is insufficient, triglyceride can be powered by B oxidation and decomposition of fatty acids. When sugar intake is excessive, triglyceride can also be synthesized by de novo synthesis. List the differences between the fatty acid beta oxidation pathway and the de novo synthesis pathway (identify at least five differences)arrow_forward
- Part A Identify each of the following metabolic pathways. Drag the appropriate labels to their respective targets. Reset Help the conversion of fatty acids to 2-carbon units of acetyl CoA ketogenesis the conversion of an amino acid to an a-keto transamination acid the combination of 2-carbon units of acetyl COA to form fatty acids oxidative deamination the removal of an amino group as NH4+ from B oxidation glutamate to yield a-ketoglutarate lipogenesis the production of ketone bodiesarrow_forwardIn fatty acid synthesis, malonyl-CoA, rather thanacetyl-CoA, is used as a “condensing group.” Suggest a reason for this.arrow_forwardDraw the Biosynthesis of fatty acids from Acetyl CoA pathway, then identify and label the different types of organic reaction mechanisms (Sn1, Sn2, E1, or E2 reaction mechanisms). Make sure to name and draw the structures of each biomolecule included in the pathway.arrow_forward
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