(a)
Interpretation: The synthetic routes for the given transformations have to be proposed
Concept Introduction:
Friedel-Crafts Alkylation: The Friedel-Crafts alkylation involves the electrophilic substitution of alkyl groups on
An azide synthesis: An azide synthesis involves the reaction between alkyl halide and sodium azide. Alkyl azide is formed in the first step. Alkyl azide on reduction with hydrogen in the presence of platinum produces primary amine. In this way, primary
Reductive amination: Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions.
To find: Propose the synthetic routes for the given transformation (a)
Apply a retrosynthetic analysis
(b)
Interpretation: The synthetic routes for the given transformations have to be proposed
Concept Introduction:
Friedel-Crafts Alkylation: The Friedel-Crafts alkylation involves the electrophilic substitution of alkyl groups on aromatic rings when arenes are treated with alkyl halides in presence of Lewis acids. This reaction is catalyzed by Lewis acids like anhydrous AlCl3, FeX3, ZnCl2, BF3 etc.
Sandmeyer reaction: Sandmeyer reactions use copper salts as the reagents. Here, aryldiazonium salt is converted into aryl halides or aryl cyanides by using copper halides or copper cyanides.
A compound containing an amino group is treated with sodium nitrite and HCl leading to the formation of diazonium salt.
To find: Propose the synthetic routes for the given transformation (b)
Apply a retrosynthetic analysis
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