Chapter 23, Problem 59IP

Interpretation Introduction

Interpretation:

The structures of compounds A, B and C for the given reaction scheme should be drawn.

Concept Introduction:

Preparation of Grignard reagents: They are prepared by reaction of organohalide in presence $Mg$ in ether solvent.

    $\begin{array}{l}\text{R-X}\underset{E{t}_{2}O}{\overset{Mg}{\to }}\text{R-Mg-X}\\ \text{here R-X}=organohalide\\ \text{R-Mg-X}=organomagnesiumhalide\end{array}$

Preparation of organozinc: They are prepared in the same way as preparation of Grignard reagents.

    $\begin{array}{l}\text{R-X}\underset{{\text{Et}}_{\text{2}}\text{O}}{\overset{\text{Zn}}{\to }}\text{R-Zn-X}\\ \text{where R-X=organo}\text{halide}\\ \text{R-Zn-X=organozinchalide }\end{array}$

Negishi coupling: It describes how the product obtained when organometallic compound containing $\text{Zn,}\text{Al}\text{and}\text{Zr}$ is coupled with organic electrophile in presence of palladium or nickel catalyst.

Stille coupling reaction: The reaction that involves coupling of an aryl, benzyl or vinyl halide or triflate with stannane in presence of $\text{Pd}{\left({\text{PPh}}_{\text{3}}\right)}_{\text{4}}$.