Concept explainers
(a) Interpretation:
The pathway for the oxidative damage done to DNA at
Should be explained.
Concept Introduction:
In the living organisms, any modification or damage to the deoxyribonucleic acid is regarded as the mutation. The oxidation of DNA produces 8-oxoguanine, which is also a damage to DNA. This can be repaired by the Base excision technique in which the base pairing is changed by 8-oxoguanine by adding in to adenine base.
(b) Interpretation:
The experiments should be proposed to test if the proposed pathway actually occurs or not.
Concept Introduction:
In the living organisms, any modification or damage to the deoxyribonucleic acid is regarded as the mutation. The oxidation of DNA produces 8-oxoguanine, which is also a damage to DNA. This can be repaired by the Base excision technique in which the base pairing is changed by 8-oxoguanine by adding in to adenine base.
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Biochemistry: Concepts and Connections (2nd Edition)
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