Biology: The Dynamic Science
4th Edition
ISBN: 9781337246422
Author: Peter J. Russell; Paul E. Hertz; Beverly McMillan
Publisher: Cengage Learning US
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Chapter 21.4, Problem 3SB
Summary Introduction
To review:
The allele that causes sickle-cell anemia is rare in human populations that are native to northern Europe.
Introduction:
HbS (sickle hemoglobin) allele encodes for the defective hemoglobin in humans. HbS allele differs from normal allele (HbA) by one amino acid. In HbS/HbS homozygotes, alleles form faulty hemoglobin, in which RBCs (red blood cells) acquire a sickle shape. Individuals containing HbS/HbS homozygotes die due to sickle cell anemia before reproducing. HbA/HbS heterozygotes offer great resistance to malaria by not allowing the
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Students have asked these similar questions
Why does sickle-cell anaemia persist in the human population when it is believed that the harmful alleles get eliminated from the population after a certain time?
The allele for sickle anemia is found at higher frequencies in central Africa than in other parts of the world. What are the advantage and disadvantages?
If, within specific regional populations over two thousand years ago, sickle-cell anemia killed those individuals born with it before they could reproduce to pass it on to offspring, how did it persist in these populations?
Group of answer choices
A-Because of late-onset of the disease.
B-Because it is cause by a virus and it spreads faster than people died.
C-Because of the basic principles of mendelian inheritance that result in some heterozygote "carrier" combinations.
D-Because malaria made it possible to survive sickle cell anemia since the parasite would carry oxygen on the blood cells with the mutated hemoglobin.
E-It does not persist. Natural selection removes the allele because people die from both malaria and sickle-cell anemia.
Chapter 21 Solutions
Biology: The Dynamic Science
Ch. 21.1 - If a population of skunks includes some...Ch. 21.1 - Prob. 2SBCh. 21.1 - What factors contribute to phenotypic variation in...Ch. 21.2 - Prob. 1SBCh. 21.2 - Why is the Hardy-Weinberg principle considered a...Ch. 21.2 - Prob. 3SBCh. 21.3 - Which agents of microevolution tend to increase...Ch. 21.3 - Which mode of natural selection increases the...Ch. 21.3 - In what way is sexual selection like directional...Ch. 21.4 - How does the diploid condition protect harmful...
Ch. 21.4 - Prob. 2SBCh. 21.4 - Prob. 3SBCh. 21.5 - How can a biologist test whether a trait is...Ch. 21.5 - Why are most organisms adapted to the environments...Ch. 21 - The reason spontaneous mutations do not have an...Ch. 21 - The phenomenon in which chance events cause...Ch. 21 - Prob. 3TYKCh. 21 - Prob. 4TYKCh. 21 - Prob. 5TYKCh. 21 - Which of the following represents an example of...Ch. 21 - A population of mice is at HardyWeinberg...Ch. 21 - If the genotype frequencies in a population are...Ch. 21 - An Eastern European immigrant carrying the allele...Ch. 21 - If a storm kills many small sparrows in a...Ch. 21 - Prob. 11TYKCh. 21 - Discuss Concepts Many human diseases are caused by...Ch. 21 - Prob. 13TYKCh. 21 - Apply Evolutionary Thinking Captive breeding...Ch. 21 - Prob. 15TYKCh. 21 - Design an experiment to test the hypothesis that...Ch. 21 - Peter and Rosemary Grant of Princeton University...
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- What would happen to the frequency of heterozygous carriers of sickle-cell anemia (with AS genotype) if mosquitoes were completely wiped out in a large region?arrow_forwardIn parts of equatorial Africa, where the malaria parasite is most common, the sickle-cell allele constitutes 20% of the ß-hemoglobin alleles in the human gene pool. The sickle cell trait provides an advantage against malaria compared to people with normal hemoglobin. In the United States, the parasite that causes malaria is not present, but African Americans whose ancestors were from equatorial Africa have the sickle-cell B- hemoglobin allele. These differences in traits illustrate O inclusive fitness because people have evolved molecular differences to adapt to environmental stimuli O inclusive fitness because ß-hemoglobin increases the proliferation of beneficial traits in the population O relative fitness because people have evolved molecular differences to an environmental pathogen O relative fitness because the molecular differences in ß-hemoglobin are passed to the next generationarrow_forwardExplain the High frequency of the sickle-cell allele HbβS in regions of Africa where malaria is prevalent?arrow_forward
- which of the following statement regarding sickle-cell disease is false? A) all of the symptoms of sickle-cell disease result from the action of just one allele.B) persons who are heterozygous for sickle-cell disease are also resistant to malariaC) about one in 10 africa americans is a carrier of sickle-cell diseas.D) sickle cell disease causes white blood cells to be sickle- shapedarrow_forwardDo you think the allele for sickle cell anemia would be common in regions where malaria did not exist? Explain why or why not.arrow_forwardIn a region of Africa, where malaria is prevalent, 40% of the population are found to have sickle-cell anemia. The disease is caused by an abnormal hemoglobin that is found in both homozygotes (S2S2) and heterozygotes (S1S2). Many homozygotes (S2S2) suffer from anemia and often die. Heterozygotes (S1S2) incur a much less debilitating malady called "sickling trait". Approximately 3% of the people with abnormal hemoglobin are homozygotes (1.2\% of the entire population). The fitness of the S2S2 homozygotes is only 1/4 that of the heterozygotes. Where malaria is prevalent, heterozygotes exhibit overdominance with respect to fitness. How would you calculate relative fitness of the S1S1 homozygotes if you're assuming the population is at an equilibrium frequency for S2?arrow_forward
- Humans who are born homozygous for the recessive sickle cell allele die of sickle cell anemia, while those who are heterozygous are resistant to malaria. 5% of the population of the Congo are homozygous recessive for the sickle cell allele. What percentage of the population is resistant to malaria?arrow_forwardSickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States. Malaria is a disease caused by a parasite that infects healthy red blood cells and can lead to death. However, the parasite is not able to infect sickle cell red blood cells. Scientists claim that the higher frequency of sickle cell carriers is due to the presence of malaria. Provide reasoning to support the claim.arrow_forwardSickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of this genetic defect causes deformation of red blood cells. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. Assuming HWE, if 9% of an African population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria…arrow_forward
- Sickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What percentage of the population will be more resistant to malaria because they are heterozygous (Ss) for the sickle-cell…arrow_forwardSickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What is the frequency of the dominant allele? Please show your work in order to receive credit.arrow_forwardSickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What is the frequency of the recessive allele? Please show your work in orderarrow_forward
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