Principles of Biology
Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 21.4, Problem 1BC
Summary Introduction

To analyze: The codons representing different amino acids and propose a change that results in a silent mutation.

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A codon is a sequence of three DNA or RNA nucleotides that corresponds with a specific amino acid. A neutral mutation is a mutation in a DNA triplet or codon which does not change the resulting amino acid. This mutation has no effect on fitness. In other words, it is neutral with respect to natural selection.

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A mutation that changes a C to a T causes a type of Ehlers-Danlos syndrome, forming a “stop” codon and resulting in shortened procollagen. Consult the genetic code and suggest one way that this can happen.
Transcribe the DNA strand given above to write the sequence of the mRNA strand in the 5’ to 3’ direction.                                                                                                                    Use the table and write the sequence of the resulting peptide.                                      Is it possible for a codon to code for another amino acid?  What will be the effect if a mutation changes the codon UAU to UAA?  What is a reading frame?                                                  If you are given a nucleotide sequence, how would you find Open Reading Frames? DISCUSS the reason why there are leading and lagging strands in replication?
DNA mutations can affect the reading frame for the genetic code. What is a human condition caused by these mutations? Identify how the reading frame is affected.
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY