The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells. Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage . They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

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Answer 1

Question

Chapter 20, Problem 10P

Summary Introduction

To explain: The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells.

Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage. They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

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Answer 2

Question

Chapter 20, Problem 10P

Summary Introduction

To explain: The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells.

Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage. They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

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Answer 3

Question

Chapter 20, Problem 10P

Summary Introduction

To explain: The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells.

Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage. They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

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Answer 4

Question

Chapter 20, Problem 10P

Summary Introduction

To explain: The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells.

Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage. They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

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Answer 5

Chapter 20, Problem 10P

Summary Introduction

To explain: The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells.

Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage. They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

Answer 6

Chapter 20, Problem 10P

Summary Introduction

To explain: The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells.

Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage. They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

Answer 7

Chapter 20, Problem 10P

Summary Introduction

To explain: The treatment with olaparib kills the cancer cells in patients having only one functional copy of Brca1 gene but does not harm normal cells.

Concept introduction: PolyADP-ribose polymerase (PARP) with their DNA binding domain detects and then binds to the Single Strand (SS) DNA damage. They synthesize Poly ADP ribose which in turn recruits the DNA repair proteins. Olaparib is a PARP inhibitor. Olaparib effectively targets and kills cells lacking DNA repair.

Answer 8

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Answer 9

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Answer 10

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Answer 11

Ch. 20 - Prob. 1P Ch. 20 - Prob. 2P Ch. 20 - Prob. 3P Ch. 20 - Prob. 4P Ch. 20 - Prob. 5P Ch. 20 - Prob. 6P Ch. 20 - Prob. 7P Ch. 20 - Prob. 8P Ch. 20 - Prob. 9P Ch. 20 - Prob. 10P

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