Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.