Chapter 18, Problem 2P

Interpretation Introduction

(a) Interpretation:

Substrate required by B enzyme should be identified.

Concept Introduction:

Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen.Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.

Interpretation Introduction

(b) Interpretation:

Compound excreted in urine because ofenzyme C deficiency in animals should be identified.

Concept Introduction:

Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.

Interpretation Introduction

(c) Interpretation:

Consistent alterations of genetic in the enzyme because of treatment by injecting B12 for the enzyme C deficiency in animals should be identified.

Concept Introduction:

Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.

Interpretation Introduction

(d) Interpretation:

Kinds of amino acid released during urine excretion of animals having genetic deficiency in animals should be identified.

Concept Introduction:

Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.