Human Physiology: An Integrated Approach (7th Edition)
Human Physiology: An Integrated Approach (7th Edition)
7th Edition
ISBN: 9780321981226
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 18, Problem 1CC

Cellular metabolism review: which of the following three metabolic pathways—glycolysis, the citric acid cycle. and the electron transport system—is directly associated with (a) O2 consumption and with (b) CO2 production?

(a)

Expert Solution
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Summary Introduction

To determine: Whether the glycolysis, the citric acid cycle, or the electron transport chain is directly related to O2 consumption.

Introduction: Glycolysis is a metabolic pathway in which conversion of glucose (6 carbon compounds) into pyruvate (3 carbon compound) takes place. Glycolysis results in the degradation of glucose and production of high energy molecules -ATP and NADPH. In the citric acid cycle, the oxidation of acetyl-CoA takes place through a series of chemical reactions to release high-energy molecules-ATP, NADH and, also CO2. In electron transport system, the redox reaction takes place to create an electrochemical proton gradient. This gradient will help in driving ATP synthesis.

Explanation of Solution

Glycolysis comprises of ten biochemical reactions to convert glucose into pyruvate. Glycolysis is the first step of cellular respiration, but it does not require oxygen for completion. The glycolysis also takes place in the anaerobic organism. The citric acid cycle is the second step of cellular respiration and provides energy molecules-NADH, FADH2 to electron transport chain after oxidation of acetyl CoA. The citric acid cycle does not require oxygen directly; it only depends on the product, which is formed in the presence of oxygen by the electron transport chain. Electron transport chain (ETC) is the part of the last step of cellular respiration. During ETC, the oxygen is consumed to form water.

Conclusion

The oxygen consumption is directly related to the electron transport system.

(b)

Expert Solution
Check Mark
Summary Introduction

To determine: Whether the glycolysis, the citric acid cycle, or the electron transport chain is directly related to CO2 production.

Introduction: Glycolysis is the first step in the splitting of glucose into pyruvates and extract energy for cellular respiration. In citric acid cycle, the acetyl CoA is modified using mitochondrial enzymes and high energy intermediates are produced. These intermediates will be used in the next step of cellular respiration. In electron transport chain, a proton gradient is formed across the inner mitochondrial membrane and .ATP synthesis is derived.

Explanation of Solution

Glycolysis is the first step of cellular respiration. The pyruvate formed at the end of glycolysis can further be oxidized to carbon dioxide and two carbon acetyl group, but this oxidation of pyruvate is not a part of glycolysis. The second step of cellular respiration is citric acid cycle which provides energy molecules-NADH, FADH2 to electron transport chain after oxidation of acetyl CoA. The reduction of NAD+ to NADH during the citric acid cycle releases CO2. Electron transport chain (ETC) is the part of the last step of cellular respiration. In electron transport chain, a proton gradient is formed across the inner mitochondrial membrane and .ATP synthesis is derived. There is no production of carbon dioxide during the electron transport chain.

Conclusion

The carbon dioxide production is directly associated with the citric acid cycle.

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Explain the regulation of cellular respiration. Include the roles of glycolysis, the citric acid cycle, the electron-transport chain, ATP synthesis, and the compartmentalization of cellular respiration in the mitochondria
Additional information: ATP production by the ETC and ATP Synthase per glucose varies somewhat depending on the energy required to move NADH into the mitochondria and other energy uses for the hydrogen-ion gradient. Additional questions: 1.) How many ATP's are generally yielded by oxidative phosphorylation from the catabolism of one glucose? 2.) Summarize the total ATP's obtained from a single molecule of glucose, from start to finish?  asap
Describe the main steps of each phase of the aerobic cellular respiration (glycolysis, pyruvate processing, the citric acid cycle, the electron transport chain, and chemiosmosis) and as well as anaerobic cellular respiration(fermentation). (bullet each step in chronological order) (draw diagrams for each phase and note the inputs and outputs)

Chapter 18 Solutions

Human Physiology: An Integrated Approach (7th Edition)

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