Essential Organic Chemistry, Global Edition
3rd Edition
ISBN: 9781292089034
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Textbook Question
Chapter 17, Problem 37P
- a. Why is the pKa of the glutamate side chain greater than the pKa of the aspartate side chain?
- b. Why is the pKa of the arginine side chain greater than the pKa of the lysine side chain?
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Why is the pKa of the glutamate side chain greater than the pKa of the aspartate side chain?
Why is the pKa of the arginine side chain greater than the pKa of the lysine side chain?
Why is the side chain Pka of amino acid so much higher ?
Chapter 17 Solutions
Essential Organic Chemistry, Global Edition
Ch. 17.1 - a. Explain why, when the imidazole ring of...Ch. 17.2 - Prob. 2PCh. 17.3 - Prob. 3PCh. 17.3 - Prob. 4PCh. 17.3 - Prob. 6PCh. 17.4 - Calculate the pI of each of the following amino...Ch. 17.4 - a. Which amino acid has the lowest pI value? b....Ch. 17.5 - What aldehyde is formed when valine is treated...Ch. 17.5 - Prob. 10PCh. 17.5 - Prob. 11P
Ch. 17.5 - Prob. 12PCh. 17.6 - Prob. 13PCh. 17.6 - What amino acid would be formed using the...Ch. 17.6 - What amino acid would be formed when the aldehyde...Ch. 17.7 - Pig liver esterase is an enzyme that catalyzes the...Ch. 17.8 - Prob. 17PCh. 17.8 - Prob. 18PCh. 17.8 - Prob. 19PCh. 17.8 - Prob. 20PCh. 17.10 - Prob. 21PCh. 17.10 - Prob. 22PCh. 17.10 - Why does cyanogen bromide not cleave on the C-side...Ch. 17.10 - Prob. 24PCh. 17.10 - Prob. 26PCh. 17.12 - Prob. 27PCh. 17.13 - a. Which would have the greatest percentage of...Ch. 17 - Draw the predominant form of the following amino...Ch. 17 - What is the pI of serine?Ch. 17 - Prob. 31PCh. 17 - Prob. 32PCh. 17 - Which would have a higher percentage of negative...Ch. 17 - Draw the form of aspartate that predominates at...Ch. 17 - Prob. 35PCh. 17 - A professor was preparing a manuscript for...Ch. 17 - a. Why is the pKa of the glutamate side chain...Ch. 17 - Prob. 38PCh. 17 - Determine the amino acid sequence of a polypeptide...Ch. 17 - Prob. 40PCh. 17 - Prob. 41PCh. 17 - Three peptides were obtained from a trypsin...Ch. 17 - Prob. 43PCh. 17 - After the polypeptide shown here was treated with...Ch. 17 - The disulfide bridges of a polypeptide were...Ch. 17 - -Amino acids can be prepared by treating an...Ch. 17 - Reaction of a polypeptide with carboxypeptidase A...Ch. 17 - Prob. 48PCh. 17 - Prob. 49PCh. 17 - Show how valine can be prepared by a. a Strecker...Ch. 17 - Prob. 51PCh. 17 - Why is proline never found in an -helix?Ch. 17 - Determine the amino acid sequence of a polypeptide...Ch. 17 - Prob. 55PCh. 17 - A chemist wanted to test his hypothesis that the...Ch. 17 - A normal polypeptide and a mutant of the...
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- Arginine has these pKa values: pka1 for the carboxyl group = 2.17, pKa2 for the amino group = 9.04, and pKaR for the side chain - 12.48 At pH 7, which groups in arginine are protonated? amino and side chain OB. none Oc ll OD. carboxyl and side chain O E. side chain onlyarrow_forward3. Pepsin cleavage of the peptide Ala-His-Gly-Trp-Val-lle-Arg-Gly would yield the peptides Ala-His-Gly-Trp and Val-Ile-Arg-Gly. 4. Argininosuccinate synthetase converts citrulline and aspartate into argininosuccinate. T F T Farrow_forwardArginine has these pKa values: pka1 for the carboxyl group = 2.17, pKa2 for the amino group = 9.04, and pKaR for the side chain - 12.48 At pH 7, which groups in arginine are protonated? amino and side chain O B. none Oç all OD. carboxyl and side chain side chain only OE.arrow_forward
- You are called in as a consult for a patient who suffers from acidosis. Urine levels of both lactic acid and isocitric acid are elevated. Mitochondria isolated from the patient’s fibroblasts oxidize pyruvate very slowly whereas α-ketoglutarate and malate are oxidized normally. a. At what enzyme would you predict the patient has a defect? b. Why? What evidence do you have to choose that enzyme? c. How do you account for the increase in lactic acid?arrow_forward0 Can the product of a reaction that is part of a sequence act as an inhibitor for another reaction in the sequence? Explain.arrow_forward22-16 Which amino acids in Table 22-1 have more than one stereocenter?arrow_forward
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