Concept explainers
Interpretation:
The
Concept Introduction:
Acid-base properties of Amino acids:
Every amino acid has a carbonyl group and an amino group, and each group can exist in an acidic form or a basic form, depending on
The compound exists primarily in the acidic form in solutions that are more acidic than their
Zwitter ion has both positive as well as negative charge, thus it is also called neutral dipolar ion.
Zwitter ion accepts proton in acidic condition and in basic condition zwitter ion lose electrons.
Isoelectric point are the
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EBK ESSENTIAL ORGANIC CHEMISTRY
- . Describe the pH range of acceptable buffering behavior for the amino acids alanine, histidine, aspartic acid, and lysine.arrow_forwardAlanine has pKa values of 2.34 and 9.69. Therefore, alanine exists predominately as a zwitterion in anaqueous solution with pH 7 ____ and pH 6 ____.arrow_forwardWhat is the ratio of CATION to ANION in Drug X? [blank1] H₂C -H Fogy CH3 SO42 'N CH3 Drug X CH3NH Describe the possible interactions between the SIDE CHAINS of amino acids: I. and II.... II. and III... I. and III... 1. COO NH3* 2 HO II. COO HO NH3* COO NH3* III.arrow_forward
- Select the correct representation of this aminoacid in aqueous solution at the stated pH values. pKa (a-CO₂H) = 2.20 pK₂ (α-NH₂) = 9.11 pKa (side chain OH) = 10.07 pl = 5.63 HO Lont out on on OH OH NH₂ NH₂ NH₁ HO NH₂ B D at pH 1 HO NH₂ of of an OH NH₂ NH₂ NH3 O E F G at pH 9.59 at pH 13. at pH 5.63 (the isoelectric point) HO OH HO [Choose ] [Choose ] [Choose ] [Choose ] an NH3 H OHarrow_forwardAll amino acids have two ionizable functional groups: an α‑amino group (average p?a of 9.4) and an α‑carboxylic acid group (average p?a of 2.2). Aspartic acid has an ionizable side chain (R group) with a p?a of about 3.8. One of the possible ionization states of aspartic acid is shown in the image. The protonated form of the R group of aspartic acid is shown in the structure. The ratio of the protonated form to the charged (deprotonated) form depends on the p?a of the R group and the pH of the solution. Select all the pH values at which the charged form of the R group would predominate.arrow_forwardThe maximum number of amino acid side chains that can potentially form an ionic bond (+ll- interaction) with the side chain of His is _at pH 21;at pH 7 and at pH 11.5 andat pH 13.5. (assume no partial charges, only +/- whole number integers) 00: 2; 3:1 01:2:4:1 O 2;2;3,0 O 0: 2; 3;0 00:2; 4: 0 00: 0; 2; 2 none of thesearrow_forward
- Sketch a titration curve for the amino acid cysteine, and indicate the pKavalues for all titratable groups. Also, indicate the pH at which cysteinehas no net charge.arrow_forwardQuestion 6 of 25 > Modify lysine to show the predominant form at pH 7. Modify the amino acid by adding or removing atoms or bonds and by adding charges where appropriate. Select Draw Rings More N 0 H / || III C H-O || C ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ H H I C *一£一£一£一£ H H I N-H Erase Q2 Qarrow_forwardA1c Select ONE peptide linkage and draw a circle around all of the atoms that would lie in a single plane. H R2 | H H;Ñ. || C. N R, H H R3 H Ilt. O=0arrow_forward
- a) if maltose is made up of two a-D-glucose units connected together by an a(1->4) linkage, how can it give a positive test as a reducing sugar in a pH=7 solutions such as Fehlings'? b) if a person produces and excudes a polyunsaturated oil from their skin, how does it ultimately make clothes smell bad, and how does baking soda remove the odor? (DETAILS!!! pH neutralizing is not enough!!) c) opioids are compounds derived from opium, which comes from the opium poppy. Although in reality, all poppies produce opioids, the drug "morphine", codeine as well as other opioid pain killers are typically derived from opium. A quick way to find or identify these compounds is to look for a six-membered ring containing a nitrogen. Often, if you see a six-membered ring with a nitrogen, you have some sort of an opioid or a modified synthetic painkiller. With that said morphine and codeine are typically not injected or given orally inpure form. Instead their salts are used, such as morphine sulfate…arrow_forwardWhich of the structures below corresponds to the dipeptide cysteylananine? The parentamino acids are shown below. но H,C-c-8-o NH, но HS-CH, c-¿-o NH, alani ne cysteine но но но "H;N-c-C-N-c-&- ČH; H CH; A. B. CH, H CH, SH SH H,C O но нс о "H,N-c-E-N-c-&-o H CH; но C. "H,N-c-c-N-ċ-E-o SH SH O H "H,N--ċ-o-o-ċ- E. c-NH" 'H. ČH, SH D.arrow_forwardAnswer the following questions on the basis of the free energies of formation at 25°C shown in the table at the top of the next page: (a) Does the peptide bond between alanine and glycine form spontaneously under standard conditions?arrow_forward
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