Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 16.1, Problem 1COMQ
Which of the following are examples of molecular changes that can have an epigenetic effect on gene expression?
a. Chromatin remodeling
b. Covalent histone modification
c. Localization of histone variants
d. DNA methylation
e. Feedback loops
f. All of the above
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Which of the following is NOT a description of an epigenetic modification?
A. regulatory patterns that persisis in the absence of the original signal
B. stable alterations in gene expression without changes to the underlying DNA sequence
C. the persistence of gene expression patterns through cell division
D. an intrinsic signal that triggers cell differentiation
Which of the following is not a major mechanism of epigenetic change?
a. DNA methylation
b. Alteration of a DNA base sequence in a promoter
c. Histone acetylation
d. Action of RNA molecules
Which of the following could represent an epigenetic modification in a cell?
A.
Deletion of chromosome 18
B.
Acetylation of histone H3
C.
Deletion of a 20-nucleotide segment of chromosome 3
D.
Conversion of an A to a T within a gene
E.
Duplication of chromosome 13
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. When mice carrying theallele exhibit a darker...Ch. 16.3 - Which of the following types of epigenetic changes...Ch. 16.4 - Prob. 1COMQ
Ch. 16.4 - Prob. 2COMQCh. 16.4 - Prob. 3COMQCh. 16.4 - Prob. 4COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 6CONQCh. 16 - Prob. 7CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 9CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 13CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 5CONQCh. 16 - Define alternative splicing. What are advantages...Ch. 16 - What is the function of a splicing factor? Explain...Ch. 16 - Figure 16.8 shows the products of alternative...Ch. 16 - Lets suppose a person is homozygous for a mutation...Ch. 16 - Prob. 20CONQCh. 16 - What are the advantages and disadvantages of mRNAs...Ch. 16 - Prob. 22CONQCh. 16 - Prob. 23CONQCh. 16 - Prob. 24CONQCh. 16 - Describe how the binding of the iron regulatory...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - E6. In Experiment 16A by Fire and Mello, were they...Ch. 16 - E7. Explain how the data of Fire and Mello...Ch. 16 - Prob. 8EQCh. 16 - 2. Discuss the similarities and differences of...Ch. 16 - How are regulatory transcription factors...
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- Tumor cells from a person with leukemia have been analyzed to determine which oncogene is involved in the transformation. After partial sequencing of the gene, the predicted gene product is identified as a tyrosine kinase. Which of the following proteins would most likely be encoded by an oncogene and exhibit tyrosine kinase activity? A. Nuclear transcriptional activator B. Epidermal growth factor C. Membrane-associated G protein D. Platelet-derived growth factor E. Growth factor receptorarrow_forwardCancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells. Which drug is most likely to help treat this patient's cancer? a. An inhibitor for HMT (histone methyltransferases) b. An inhibitor for HDM (histone demethylases) c. An inhibitor for HDACs (histone deacetylases) d. An inhibitor for HATs (histone acetyltransferase)arrow_forwardA cell is homozygous for a LOF mutation in the histone acetyltransferase (HAT) gene. Which of the following is/are true? a. Chromatin in the cell will be more condensed than usual, decreasing expression of genes that should be expressed. b. This will lead to histones with more positive charges on their tails, increasing the interaction between histones and the DNA backbone. c. This will lead to a decrease in DNA methylation and therefore cause an increase in gene expression. d. Chromatin in the cell will be less condensed than usual, increasing expression of genes that should not be expressed.arrow_forward
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