Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 16, Problem 4ITD
Summary Introduction
To review:
The data needed to make a conclusion about effectiveness of preventive surgeries.
Introduction:
Cancer is a disease developed due to uncontrolled cell division leading to formation of abnormal growth called tumors. It is a genetic disease in which there are changes in the genes due to certain mutations. Successive alterations in genes gradually lead to the conversion of normal cells to cancer cells. Some cancers are hereditary and called familial cancer.
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Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor biology, what is the mutator phenotype hypothesis? What are some ways in which error-prone polymerases could be targeted for potential anti-cancer treatments?
please help
In Demircioglu et al (2019), the authors found that promoter switching for the ERBB2 gene was
often associated with mutations in other known oncogenes and tumor suppresor genes. However,
they argued that promoter switching may be correlated with cancer development and progression
regardless of additional mutations. What evidence did they have to support this idea ?
O They found that patients who had ERBB2 promoter switching but no other mutations in known oncogenes
(OG) and tumor suppressor genes (TSG) carried many other mutations in genes that may have contributed to
cancer progression and had not been identified as OG or TSG yet.
O They saw that patients that showed promoter switching but did not have any other identifiable mutations had
poorer prognosis than patients without promoter switching
This was actually a discussion point; the authors did not have any experimental evidence to support their
claim.
O They treated all patients that showed promoter switching with the same drug…
Chapter 16 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 16.1 - Suppose the lacl gene is mutated so that the Lac...Ch. 16.1 - Answer the equivalent question for the trp operon:...Ch. 16.2 - What is the role of histones in gene expression?...Ch. 16.2 - Prob. 2SBCh. 16.3 - Prob. 1SBCh. 16.3 - Prob. 2SBCh. 16.4 - Prob. 1SBCh. 16.4 - Prob. 2SBCh. 16.5 - Prob. 1SBCh. 16.5 - Prob. 2SB
Ch. 16.5 - Prob. 3SBCh. 16.5 - Prob. 4SBCh. 16 - Prob. 1TYKCh. 16 - For the E. coli lac operon, when lactose is...Ch. 16 - Prob. 3TYKCh. 16 - Prob. 4TYKCh. 16 - Prob. 5TYKCh. 16 - Prob. 6TYKCh. 16 - Prob. 7TYKCh. 16 - Prob. 8TYKCh. 16 - Prob. 9TYKCh. 16 - Prob. 10TYKCh. 16 - Discuss Concepts In a mutant strain of E. coli,...Ch. 16 - Prob. 12TYKCh. 16 - Prob. 13TYKCh. 16 - Prob. 14TYKCh. 16 - Design an experiment using rats as the model...Ch. 16 - Prob. 1ITDCh. 16 - Prob. 2ITDCh. 16 - Prob. 3ITDCh. 16 - Prob. 4ITD
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