Biochemistry
Biochemistry
8th Edition
ISBN: 9781464126109
Author: Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr., Lubert Stryer
Publisher: W. H. Freeman
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Chapter 16, Problem 1P
Interpretation Introduction

Interpretation:

The reason for the difference in gross value and the net value of ATP formation in glycolysis needs to be explained.

Concept Introduction :

Glycolysis, also termed as the Embden-Meyerhof pathway is an oxidative pathway in which one mole of glucose is converted into two moles of pyruvate. Glycolysis occurs in the cytosol of the cells. It occurs in both aerobic and anaerobic organisms and does not include molecular oxygen.

Expert Solution & Answer
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Explanation of Solution

Glycolysis is divided into two phases, the preparatory phase, and the payoff phase. During the preparatory phase, energy is consumed, but during the payoff phase, energy is produced by the process. The gross energy value is the total amount of energy produced by the glycolysis process. In the payoff phase, four molecules of ATP are produced in the form of energy. The net energy value is the amount of energy actually produced by the glycolysis process. This value takes into account the total energy consumed by the glycolysis process. So, two molecules of ATP are used in the pathway and four ATP molecules are produced, then net ATP production is of two molecules. Due to this, gross and net value for ATP is different in glycolysis.

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Long explanations are NOT NEEDED. I pretty much have an idea already about this lesson, I would just like to see if my answers are correct, if it's wrong then kindly correct and just add a short explanation. ATP accounting. Consider 1 molecule of the sucrose (monomeric units: glucose and fructose) that will undergo complete oxidation. a. Number of pyruvate molecules after glycolysis is 4.b. Net ATP produced in glycolysis only (via substrate-level phosphorylation) is 2.c. Number of NADH produced using the pyruvate dehydrogenase complex reaction is 1.d. Number of NADH and FADH2 produced from Krebs cycle is 12 and 4 respectively.e. Net ATP produced (complete oxidation via Malate aspartate shuttle) is 64.
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