Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Chapter 13, Problem 9Q
Conduct research on clonal deletion and write a paragraph that explains it to a typical high school biology student.
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Chapter 13 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 13.1 - Prob. 1AYPCh. 13.1 - Compare the terms antigen, immunogen, and epitope.Ch. 13.1 - Prob. 3AYPCh. 13.1 - Prob. 4AYPCh. 13.1 - Describe the major histocompatibility complex in...Ch. 13.1 - Prob. 1NPCh. 13.2 - Prob. 6AYPCh. 13.2 - Prob. 7AYPCh. 13.2 - Prob. 8AYPCh. 13.2 - Prob. 9AYP
Ch. 13.2 - Prob. 1MMCh. 13.2 - Prob. 2MMCh. 13.3 - List characteristics of antigens that optimize...Ch. 13.3 - Prob. 11AYPCh. 13.3 - Prob. 12AYPCh. 13.3 - Prob. 2NPCh. 13.4 - Prob. 13AYPCh. 13.4 - Explain how naive T cells become sensitized to an...Ch. 13.4 - Prob. 15AYPCh. 13.5 - Diagram the steps in B-cell activation, including...Ch. 13.5 - Prob. 17AYPCh. 13.5 - Explain the various end results of antibody...Ch. 13.5 - Prob. 19AYPCh. 13.5 - Draw and label a graphwith time on the horizontal...Ch. 13.6 - Prob. 21AYPCh. 13.6 - Discuss the qualities of an effective vaccine.Ch. 13.6 - Name the two major categories of vaccines and then...Ch. 13.6 - Explain the principle of herd immunity and the...Ch. 13.6 - 3. Which characteristic is associated with passive...Ch. 13 - A single bacterium has _______ epitope(s). a. a...Ch. 13 - Prob. 2QCh. 13 - Provide an explanation to refute the following...Ch. 13 - The primary B-cell receptor is a. IgD. b. IgA. c....Ch. 13 - Name three antigen-presenting cells, and what...Ch. 13 - Major histocompatibility molecules are critical...Ch. 13 - In humans, B cells mature in the ___ and T cells...Ch. 13 - Explain how the memory response is the cornerstone...Ch. 13 - Conduct research on clonal deletion and write a...Ch. 13 - Which of the following cells is capable of...Ch. 13 - Is antibody diversity generated at the DNA or RNA...Ch. 13 - In order for gene rearrangement of antigen...Ch. 13 - Prob. 13QCh. 13 - Prob. 14QCh. 13 - Using the details of T-cell activation, suggest a...Ch. 13 - A vaccine that contains parts of viruses is called...Ch. 13 - Explain how herd immunity works to protect the...Ch. 13 - Prob. 18QCh. 13 - Prob. 19QCh. 13 - Chronic lymphocytic leukemia leads to the...Ch. 13 - Prob. 21QCh. 13 - Prob. 1VC
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- A young child with cretinism is not growing and her parents would like her to take synthetic hGH. Will this treatment help the child? Explain your answerarrow_forwardResearchers can make monoclonal antibodies by immunizing a mouse with a molecule (or with a microorganism). The resulting antibody-mediated response produces a set of antibodies that recognize different parts of the molecule. The mouse's B cells are then harvested from its spleen and fused with cancerous B cells from a myeloma cell line. The resulting hybrid myeloma ("hybridoma") cells are cloned: Individual cells are grown in tissue culture as separate cell lines. Each cell line produces and secretes antibodies that recognize one part of the immunizing molecule. These antibodies are called monoclonal antibodies, and they can be purified and used for research or other purposes. Monoclonal antibodies are effective for passive immunization, but only in the immediate term. Antibodies produced by one's own immune system can last up to about six months in the bloodstream, but monoclonals delivered in passive immunization often last for less than a week. Why the difference?arrow_forwardWrite correct and sequence optionarrow_forward
- Discuss the life cycle of HIV. Include in your answer a discussion of HIV genes, pay particular attention to the significance of the HIV REV gene.arrow_forwardA young child with cretins is not growing and parents would like her to take synthetic hGH. Will this treatment help the child. Explain your answerarrow_forwardWhat is monoclonal antibodies? How it can be categorized. (Subject: Biotechnology)arrow_forward
- What is a Biomarker? In one or two sentencesarrow_forwardTo detect the protein in Western blotting, antibody is used antigen is used DNA probe is used RNA probe is usedarrow_forwardClassify each statement as either true or false. True Answer Bank One disadvantage of DNA vaccines is that they don't generate significant immunologic memory. Live, attenuated vaccines are more likely to induce cell-mediated immunity than are killed, inactivated vaccines. A DNA vaccine only induces an immune response to a single epitope. Falsearrow_forward
- Would it be effective to use an inhibitor of RNA polymerase to block the HIV replication cycle and subsequent infection of human T cells? Yes, this would stop the transcription of viral genes and prevent HIV from being able to replicate. No, these types of inhibitors do not exist and would be impossible to make. No, this would block transcription of T cell genes, leading to the death of T cells and compromised immune systems in individuals. Yes, inhibitors of RNA polymerase are easy and relatively inexpensive to produce and make good therapeutics.arrow_forwardShould he go ahead and enroll on the chance that he would receive the DNA vaccine and that it would be more effective than chemotherapy? Bruce and his parents moved to a semi-tropical region of the United States when he was about 3 years old. He loved to be outside year-round and swim, surf, snorkel, and play baseball. Bruce was fair-skinned, and in his childhood years, was sunburned quite often. In his teen years, he began using sunscreens, and although he never tanned very much, he did not have the painful sunburns of his younger years. After graduation from the local community college, Bruce wanted an outdoor job and was hired at a dive shop. He took people out to one of the local reefs to snorkel and scuba dive. He didnt give a second thought to sun exposure because he used sunscreen. His employer did not provide health insurance, so Bruce did not go for annual checkups, and tried to stay in good health. In his late 20s, Bruce was injured trying to keep a tourist from getting caught between the dive boat and the dock. He went to an internist, who treated his injury and told Bruce he was going to give him a complete physical exam. During the exam, the internist noticed a discolored patch of skin on Bruces back. She told him that she suspected Bruce had skin cancer and referred him to a dermatologist, who biopsied the patch. At a follow-up visit, Bruce was told that he had melanoma, a deadly form of skin cancer. Further testing revealed that the melanoma had spread to his liver and his lungs. The dermatologist explained that treatment options at this stage are limited. The drugs available for chemotherapy have only temporary effects, and surgery is not effective for melanoma at this stage. The dermatologist recommended that Bruce consider entering a clinical trial that was testing a DNA vaccine for melanoma treatment. These vaccines deliver DNA encoding a gene expressed by the cancer cells to the immune system. This primes the immune system to respond by producing large quantities of antibodies that destroy melanoma cells wherever they occur in the body. A clinical trial using one such DNA vaccine was being conducted at a nearby medical center, and Bruce decided to participate. At the study clinic, Bruce learned that he would be in a Phase Ill trial, comparing the DNA vaccine against the standard treatment, which is chemotherapy, and that he would be randomly assigned to receive either the DNA vaccine or the chemotherapy. He was disappointed to learn this. He thought he would be receiving the DNA vaccine.arrow_forwardDescribe the process of replication of retroviruses. (You can use HIV as an example). Details are required, including the names of key enzymes involved. More than 10 sentences are required to get full credit.arrow_forward
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