Concept explainers
To explain: Identify whether the pancreatic hormone somatostatin requires a receptor on the surface or in the cytosol of a target cell.
Concept introduction: Somatostatin is a peptide hormone produced by the delta cells of pancreas. The function of somatostatin is to inhibit the growth hormone.
Answer to Problem 1E
Correct answer: Somatostatin requires a cell-surface receptor.
Explanation of Solution
Hormones are of two types, namely, steroid hormones and peptide hormones. Steroid hormones are lipid soluble and hydrophobic. Therefore, they can easily pass through the lipid bilayer on the cell surface. A receptor on the surface of the corresponding cell surface alone is sufficient to carry out functions of steroid hormones. On the other hand, peptides hormones are hydrophilic; therefore, they cannot pass through the lipid bilayer. They require a receptor on the lipid bilayer that constitutes the cell surface in order to start a cascade that activates other cell molecules to execute the functions in the cell. As somatostatin is a peptide hormone, it requires a cell-surface receptor.
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