Anatomy & Physiology: An Integrative Approach
2nd Edition
ISBN: 9780078024283
Author: Michael McKinley Dr., Valerie O'Loughlin, Theresa Bidle
Publisher: McGraw-Hill Education
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Chapter 12, Problem 3CSL
Summary Introduction
To determine:
The certain type of channel which is impaired by neurotoxins.
Concept introduction:
The neurotoxin is a type of toxin which affects the nervous tissues. Neurotoxin belongs to the class of exogenous chemical that adversely affects the functioning and structure of the nervous system. It will affect the functioning of both mature and developing nervous system. This neurotoxin prevents the depolarization stage of an action potential.
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What would happen if the drug blocked K+ channels instead?
A neurotoxin was delivered to a patient that prevented sodium channels from opening at the axon level. How does this affect a neuron's ability to communicate to other neurons? Explain in terms of action potential conductance, and neurotransmitter exocytosis at the axon terminal.
Action potential conduction velocity is higher in a myelinated axon compared to an unmyelinated axon because …
Question 1 options:
a) the diameter of a myelinated axon is greater than the diameter of an unmyelinated axon.
b) a myelinated axon has more voltage-gated sodium channels than an unmyelinated axon.
c) less axonal membrane is exposed to the ECF in a myelinated axon compared to an unmyelinated axon.
d) answers (a) and (b) are both correct; answer (c) is incorrect
e) answers (a), (b) and (c) are all correct
Chapter 12 Solutions
Anatomy & Physiology: An Integrative Approach
Ch. 12.1 - Prob. 1WDYLCh. 12.1 - What are the two primary functional divisions of...Ch. 12.2 - Prob. 3WDYLCh. 12.2 - Prob. 4WDYLCh. 12.2 - Prob. 5WDYLCh. 12.2 - Prob. 6WDYLCh. 12.2 - Prob. 7WDYLCh. 12.2 - What are the three connective tissue wrappings in...Ch. 12.3 - Prob. 9WDYLCh. 12.4 - If a person has a brain tumor, is it more likely...
Ch. 12.4 - Prob. 11WDYLCh. 12.4 - Prob. 12WDYLCh. 12.4 - Prob. 13WDYLCh. 12.5 - Prob. 14WDYLCh. 12.5 - Prob. 15WDYLCh. 12.6 - Prob. 16WDYLCh. 12.6 - Prob. 17WDYLCh. 12.7 - Prob. 18WDYLCh. 12.7 - Prob. 19WDYLCh. 12.7 - Prob. 20WDYLCh. 12.8 - How are EPSP and IPSP graded potentials...Ch. 12.8 - Prob. 22WDYLCh. 12.8 - How does depolarization and repolarization occur...Ch. 12.8 - Prob. 24WDYLCh. 12.8 - Prob. 25WDYLCh. 12.9 - Prob. 26WDYLCh. 12.9 - Prob. 27WDYLCh. 12.9 - Prob. 28WDYLCh. 12.9 - Prob. 29WDYLCh. 12.10 - Prob. 30WDYLCh. 12.10 - Prob. 31WDYLCh. 12.11 - Prob. 32WDYLCh. 12.11 - Prob. 33WDYLCh. 12 - _____ 1. The cell body of a neuron does all of the...Ch. 12 - Prob. 2DYKBCh. 12 - Prob. 3DYKBCh. 12 - Prob. 4DYKBCh. 12 - Prob. 5DYKBCh. 12 - Prob. 6DYKBCh. 12 - _____ 7. An action potential is generated when...Ch. 12 - Prob. 8DYKBCh. 12 - Prob. 9DYKBCh. 12 - Prob. 10DYKBCh. 12 - What are the four structural types of neurons? How...Ch. 12 - Prob. 12DYKBCh. 12 - How does myelination differ between the CNS and...Ch. 12 - Describe the procedure by which a PNS axon may...Ch. 12 - Prob. 15DYKBCh. 12 - Prob. 16DYKBCh. 12 - Explain summation of EPSPs and IPSPs and the...Ch. 12 - Graph and explain the events associated with an...Ch. 12 - Prob. 19DYKBCh. 12 - Prob. 20DYKBCh. 12 - Prob. 1CALCh. 12 - Prob. 2CALCh. 12 - Prob. 3CALCh. 12 - Prob. 4CALCh. 12 - Sarah wants to call her new friend Julie and needs...Ch. 12 - Over a period of 6 to 9 months, Marianne began to...Ch. 12 - Prob. 2CSLCh. 12 - Prob. 3CSL
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- a) In the absence of K+ leak channels, what would happen to the resting membrane potential of a neuron? Why is this the case? b) Depolarization of the axon membrane opens voltage-gated Na+ channels. By what mechanism does opening of these Na+ channels open other voltage-gated Na+ channels downstream of the action potential? c) Following an action potential, how does the neuron return to its resting membrane potential?arrow_forwardA) What is the point A on the graph? Define this term. B) What ions are moving at B on the graph, what direction are they moving and what type of channel is it? C) What ions are moving at C on the graph, what direction are they moving and what type of channel is it? D) If we used a chemical on the nerve at point B that prevented the channels for C from opening what would happen to the action potential?arrow_forwardThe difference between the channels along the axon and the channels in the axon terminal is that? a) axon channels are voltage-gated sodium channels and axon terminal channels are voltage-gated calcium channels b) there is no difference c) axon channels are voltage-gated sodium channels and axon terminal channels are ligand- gated sodium channelsarrow_forward
- When proteins are needed in the presynaptic terminal, they must be made in the neurosoma, which is sometimes far away and transported down the axon to the terminal. Why do you think they cannot simply be made locally, in the terminal itself?arrow_forwardLet’s say the synapses of a neuron’s dendrites are filled with glutamate-gated channels which, when activated by glutamate, cause an excitatory postsynaptic potential (EPSP) in the neuron. In one instance, glutamate is released at all of the synapses simultaneously and this leads to an action potential in the neuron. A) What type of summation of PSPs is this? Why? B) List the sequence of steps that occur starting from binding of glutamate to the glutamate-gated channels at the synapses and ending with the membrane potential at the axon hillock returning to resting potential at the end of the action potential. (Include all the changes in voltage-gated channels underlying the action potential.)arrow_forwardHow do proteins and other chemicals synthesized in the soma get to the axon terminals? By what process can a virus that invades a peripheral nerve fiber get to the soma of that neuron?arrow_forward
- Which of the following is the role of axonal Calcium (Ca2+) channels in neuronal communication at the synapse? a) they inhibit the action potential causing it to stop b) Calcium channels have no role in this process c) by allowing calcium to exit the cell, they promote the propagation of action potential across the synapse by creating depolarization d) by blocking calcium entrance, they mediate the contraction of presynaptic axon to facilitate movement e) when they open, calcium enters the presynaptic terminal, promoting fusion of neurotransmitter vesicles with presynaptic membrane, and release of neurotransmitters to the synaptic cleftarrow_forwardWhat is the role of calcium in neuronal communication at the axon terminal? What would be prevented if calcium channels could not open here in the terminal?arrow_forwardAfter discussing his case with his physician, he learned that he had probably been the victim of pufferfish poisoning. The active toxin in the tissues of this fish is a chemical called tetrodotoxin (TTX). Tetrodotoxin is in a class of chemicals known as neurotoxins because it exerts its effects on neurons. The specific action of tetrodotoxin is that it blocks voltage-gated sodium ion channels. Define the following phrases and terms associated with the signs and symptoms of Dr. Westwood’s TTX poisoning: diaphoresis motor dysfunction paresthesias cyanotic hypoventilating bradycardia gastric lavage oxygen saturation As mentioned in the case description, tetrodotoxin is a molecule that blocks voltage-gated sodium ion channels. What is a voltage-gated sodium ion channel and what is its function? When nerve cells are at rest, there is an unequal amount of positive and negative charges on either side of a nerve cell membrane. This charge difference creates an electrical potential.…arrow_forward
- Action potentials are changes in membrane potential that are localized to a small area of the plasma membrane. However, an action potential can trigger the formation of a new action potential nearby. This cycle can repeat to produce conduction of the action potential down the length of the axon. Explain this process.arrow_forwardDepression is a condition in which sufferers may feel low mood, lack of motivation and sleep. It is caused by a lack of serotonin in the synaptic cleft of neurone pathways. Serotonin is a neurotransmitter. a) Describe how serotonin acts as a neurotransmitter. Using your understanding of synaptic transmission, explain how communication between neurones in serotonin pathways of the brain would be affected in someone with depression. b) Doctors use tubocurarine drug as an anaesthetic as it temporarily paralyses muscles. It blocks receptors at neuromuscular junctions. Why does this lead to paralysis?arrow_forwardThe graph shows a tracing of membrane potential change during the course of an action potential in a typical neuron. Predict the effect of exposure to the following neurotoxins. Briefly explain how you would expect the action potential to change in the presence of each toxin and why. A toxin produced by puffer fish which specifically binds to voltage-gated sodium channels and blocks the flow of sodium ions through the channel. A toxin found in scoprion venom which slows the closure of voltage-gated sodium channel inactivation gates. Assume that the cell is normally brought to threshold by an electrical stimulus applied to it, so that any change is due only to the presence of the toxin Precise values for voltage and duration are not important, just a general trend in how the action potential may differ from the typical trace shown is expected.arrow_forward
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