Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 12, Problem 15PIAT
In normal cells, stathmin is inactivated by phosphorylation at the start of M phase. Phosphatases remove these phosphates as the cell transitions from M phase to G1. What enzyme is likely to be responsible for phosphorylating stathmin during M phase?
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Students have asked these similar questions
Stathmin is phosphorylated by cyclin dependent kinases in response to extracellular signals such as growth factors. To further understand the role of phosphorylation in stathmin function, you decide to
treat cells with growth factors in the presence or absence of phosphatase and observe microtubule dynamics. Based on the known function of stathmin, and phosphorylation of stathmin, how would you
expect phosphatase treatment to affect microtubule dynamics?
A. Decreased frequency of catastrophe in the presence of phosphatase, compared to untreated control
B. Increased frequency of catastrophe in the presence of phosphatase, compared to untreated control
C. Rapid microtubule polymerization in the presence of phosphatase, compared to untreated control
D. Catastrophe frequency is the same in phosphatase treated and control cells
Which of the following changes to the microtubule binding protein, Tau, commonly occurs in Alzheimerâ s and other neurodegenerative diseases?
A
Tau is hypo-phosphorylated and does not bind to microtubules to destabilize them.
B
Tau levels are so low in the cell that they only bind to some microtubules.
C
Tau is hyper-phosphorylated and does not bind to microtubules to stabilize them.
D
Microtubules are hyper-phosphorylated and do not bind to Tau.
Which of the following is false about cyclin-cdk complexes?
OCdk's do not have to bind to cyclin proteins for complex to be active.
OCdk/cyclin complexes phosphorylates proteins required to trigger next cell cycle
phase.
Process acts as molecular brakes to ensure cell is ready to continue with cell cycle.
O Cyclin concentrations increase gradually, but cdk must be phosphorylated by specific
kinase for complex to be active
Chapter 12 Solutions
Biological Science (7th Edition)
Ch. 12 - 1. Which statement about the daughter cells...Ch. 12 - After S phase, what comprises a single chromosome?...Ch. 12 - Progression through the cell cycle is regulated by...Ch. 12 - 4. What major events occur during anaphase of...Ch. 12 - 5. Identify at least two events in the cell cycle...Ch. 12 - 6. What evidence suggests that during anaphase,...Ch. 12 - 7. Evaluate each of the following defects. Which...Ch. 12 - Prob. 8TYUCh. 12 - Prob. 9TYPSSCh. 12 - Prob. 10TYPSS
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