Concept explainers
To determine: The effects on growth of a homozygous knockout of enzyme 3 in the amino acid biosynthetic pathway [A-B-C-D- amino acid] which were catalysed by Enzymes 1,2,3 and 4 respectively.
Introduction: The gene knockout is now a day becomes very important key point to study the gene impacts and its importance in the genetics.
Explanation of Solution
The below amino acid pathway is, in which at every step an enzyme is consumed to produce the next one:
Since the above-mentioned pathway shows homozygous knocked out of enzyme 3, which supports One Gene One Enzyme hypotheses, in that case, the pathway stops after C, as there is no enzyme present which converts the C to D in the above pathway.
To determine: The means by which the points by these impacts be redressed.
Introduction: In heterozygous knockout one gene from the allele is knocked out while in homozygous both the genes from the same allele are knocked out.
Explanation of Solution
The below pathway is supported by one gene-one enzyme hypothesis. The enzyme 3 is absent after homozygous knocking out due to which the fourth step is not completed yet.
Hence, knockouts of
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