You have sequenced a few individuals in the population and found out that there are only two alleles in the population: one is GGGTCC and the other GGGTAC. You also knew that the DNA sequence encodes two amino acid residues. The mutation responsible for the difference is an insertion mutation a transition mutation nonsynonymous mutation a neutral mutation a silent mutation

You have sequenced a few individuals in the population and found out that there are only two alleles in the population: one is GGGTCC and the other GGGTAC. You also knew that the DNA sequence encodes two amino acid residues. The mutation responsible for the difference is an insertion mutation a transition mutation nonsynonymous mutation a neutral mutation a silent mutation

Name: You have sequenced a few individuals in the population and found out t
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Description: You have sequenced a few individuals in the population and found out that there are only two alleles in the population: one is GGGTCC and the other GGGTAC. You also knew that the DNA sequence encodes two amino acid residues. The mutation responsible

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 11QP: Two types of mutations discussed in this chapter are (1) nucleotide changes and (2) unstable genome...

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A nonsynonymous mutation is also referred to as missense mutation. Which of the following correctly describe these mutations? They are permanent and cannot revert or reverse mutate back into a wild-type sequence. They cause a non-functional amino acid to replace a functional amino acid. O They result in the insertion or deletion of a small number of nucleotides to the DNA. They change the nucleotide sequence of a gene but do not change the sequence of the resulting protein. None of the provided answers are correct. They convert a codon for a particular amino acid within a gene into a stop codon. They insert an additional amino acid into the final protein product.
Two types of mutations discussed in this chapter are (1) nucleotide changes and (2) unstable genome regions that undergo dynamic changes. Describe each type of mutation.
As discussed, the overall rate of mutations in humans is estimated to be about 1 × 10−8 mutations per base pair per generation. How many new mutations would you expect each person to carry, on average, based on this mutation rate? Other studies have estimated that each person carries about 100 new loss-of-function mutations. How does this number compare with your estimate of the number of mutations based on the mutation rate? What might account for any differences?
You have a patient in your clinic presenting symptoms of cystic fibrosis. You screen their CFTR gene for mutations, and find the following list: CFTR 320 L V CFTR 341 S W CFTR 528 E D CFTR 976 F Q CFTR 1235 S R Which mutation(s) are likely causing cystic fibrosis in this patient? You also sequence a newborn family member of this patient. They have all of these same mutations, other than the one at position 976, and no other mutations in CFTR. Do you predict this person will develop cystic fibrosis? Explain why.
2. A reversion is a mutation that returns a mutant codon back to a codon that gives a wild-type phenotype. At the DNA level, this type of mutation can be an exact reversion or an equivalent reversion. GAG First GTG Exact GAG (glutamic acid) mutation (valine) reversion (glutamic acid) GAG - GTG First Equivalent (valine) reversion GAA (glutamic acid) mutation (glutamic acid) GAG First GTG Equivalent - GAT (glutamic acid) mutation (valine) reversion (aspartic acid) An equivalent reversion produces a protein that is equivalent to the wild type in structure and function. This can occur in two ways. In some cases, the reversion produces the wild-type amino acid (in this case, glutamic acid), but it uses a different codon than the wild-type gene. Alternatively. an equivalent reversion may substitute an amino acid structurally similar to the wild-type amino acid. In our example, an equivalent reversion has changed valine to an aspartic acid. Because aspartic and glutamic acids are structurally…
The genetic alteration responsible for sickle-cell anemia in humans involves: a transition mutation from A to G, substituting glutamic acid for valine in a-globin a transversion mutation from T to A, substituting valine for glutamic acid in b-globin a transition mutation from T to C, substituting valine for glutamic acid in b-globin a transversion mutation from G to C, substituting glutamic acid for valine in a-globin a frameshift mutation of one ATC codon, removing glutamic acid from b-globin
A specific single nucleotide variation in the human genome occurs with -2.5% frequency in the general population. This variation occurs within the protein coding region and results in an alanine where glycine is commonly found. This variant can best be described as a: Missense mutation Nonsynonymous coding single nucleotide polymorphism Non-coding single nucleotide polymorphism Synonymous coding single nucleotide polymorphism Sense mutation
Which type of mutation is simulated in the following example? Wild type: THE ONE BIG FLY HAD ONE RED EYE Mutant: THE ONE BUG FLY HAD ONE RED EYE
Which of the following is a transition mutation? OC --> G O C --> T OC--> A
Which of the following is a transition mutation? OG --> T G --> A G --> C
The table below shows different types of mutations in different positions in four genes. Choose the letter (A to E), from the drop-down menu, that represents the most likely type of protein that will be produced from each of these mutated genes. A: completely normal protein B: functional protein with ONE amino acid different from normal C: non-functional protein with ONE amino acid different from normal D: non-functional protein with MANY amino acids different from normal E: no protein at all Answer Type of mutation Position of mutation in gene (A, B, C, D, or E) before the part of the gene that specifies the active site of the enzyme 2 base pair insertion Inonsense immediately before the stop codon in the part of the gene that specifies the active site of the enzyme silent 1 base pair insertion in an intron
Some mutations affect changes in protein structure and function that can result in disease whereas other mutations have no significant effects on protein structure and function. Please explain reasons for the above mentioned statement. Human civilization has resulted in a large number of potentially mutagenic chemicals (e.g. pesticides) and has changed the environment to increase the likelihood of encountering other mutagens, especially UV radiation. What roles should the authorities play in identifying mutagens and regulating their release into the environment?