You expect that a lung tumor cell line has arisen due to aberrant expression of the growth factor receptor kit. The kit gene is a tyrosine kinase growth factor receptor that is activated by the growth factor called Stem Cell Factor. There is no evidence that the amino acid sequence of the kit gene is altered. Western blot determination of protein expression in lung cells from two cancer patients (lanes 1 and 2) and a normal donor (Lane 3) are depicted below. Given this data explain the likely mechanism of how the altered expression of kit is leading to a proliferative state (limit 4-5 sentences). 1 2 3 ) SCF c-kit (125 kDa) 38 kDa 35 kDa
You expect that a lung tumor cell line has arisen due to aberrant expression of the growth factor receptor kit. The kit gene is a tyrosine kinase growth factor receptor that is activated by the growth factor called Stem Cell Factor. There is no evidence that the amino acid sequence of the kit gene is altered. Western blot determination of protein expression in lung cells from two cancer patients (lanes 1 and 2) and a normal donor (Lane 3) are depicted below. Given this data explain the likely mechanism of how the altered expression of kit is leading to a proliferative state (limit 4-5 sentences). 1 2 3 ) SCF c-kit (125 kDa) 38 kDa 35 kDa
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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Transcribed Image Text:You expect that a lung tumor cell line has arisen due to aberrant expression of the growth factor receptor kit. The kit gene is a tyrosine
kinase growth factor receptor that is activated by the growth factor called Stem Cell Factor. There is no evidence that the amino acid
sequence of the kit gene is altered. Western blot determination of protein expression in lung cells from two cancer patients (lanes 1 and
2) and a normal donor (Lane 3) are depicted below. Given this data explain the likely mechanism of how the altered expression of kit is
leading to a proliferative state (limit 4-5 sentences).
1
2
3
SCF
▶
c-kit
(125 kDa)
38 kDa
35 kDa
=
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