You are studying a gene that controls ossicone (horn) length in giraffes. The wild type long-ossicone allele (L) is dominant to the mutant short-ossicone (I) allele. However the L allele is only 60% penetrant. You cross a long-horn heterozygous giraffe to a short- horn giraffe. What phenotypic progeny classes do you expect and at what frequencies?
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- Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?In Drosophila, ebony body colour is produced by a recessive gene a and wild-type (gray) body colour by its dominant allele a+. Vestigial wings are governed by a recessive gene vg, and normal wing size (wild type) by its dominant allele vg+. If wild-type dihybrid flies are crossed and produce 256 progeny, how many of these progeny flies are expected in each phenotypic class?IN DROSOPHILA, AN X-LINKED RECESSIVE MUTATION, Xm CAUSES MINIATURE WINGS. LIST THE F₂ PHENOTYPIC RATIOS IF: A MINIATURE-WINGED FEMALE IS CROSSED WITH A NORMAL MALE AND A MINIATURE-WINGED MALE IS ● ● CROSSED WITH A NORMAL FEMALE. WHAT WOULD THE PHENOTYPIC RATIO FROM (A) BE IF THE MINIATURE- WINGED GENE WERE AUTOSOMAL? ASSUME IN ALL CASES THAT THE P1 INDIVIDUALS ARE TRUE-BREEDING.
- You believe that the gene you're investigating, eyes absent, is an autosomal recessive mutant allele F7 ge in Drosophila. You set up a cross between a true-breeding mutant male and a true-breeding wildtype female to obtain the F1 generation. You then cross the F1 flies. In the F2 offspring, you observe the following: 237 wild-type males 180 wild-type females 70 mutant males 83 mutant females Based on these findings, is the mutant allele autosomal recessive? How do you know?You have a Drosophila line that is homozygous for autosomal recessive alleles a, b, and c, linked in that order. Youcross females of this line with males homozygous for thecorresponding wild-type alleles. You then cross the F1 heterozygous males with their heterozygous sisters. You obtain the following F2 phenotypes (where letters denoterecessive phenotypes and pluses denote wild-type phenotypes): 1364 + + +, 365 a b c, 87 a b +, 84 + + c,47 a + +, 44 + b c, 5 a + c, and 4 + b +.a. What is the recombinant frequency between a andb? Between b and c? (Remember, there is no crossingover in Drosophila males.)b. What is the coefficient of coincidence?In Drosophila, an X-linked recessive mutation, Xm causes miniature wings. List the F2 phenotypic ratios if: a miniature-winged female is crossed with a normal male and a miniature-winged male is crossed with a normal female. What would the phenotypic ratio from (a) be if the miniature-winged gene were autosomal? Assume in all cases that the P1 individuals are true-breeding.
- A recessive allele causes Drosophila to have white eyes instead of wild-type eyes. This eye colourgene is known to be X-linked. In a cross between homozygous wild-type females and white-eyedmales, all F1 progeny have wild-type eyes. What ratio of wild-type to white-eyed progeny can be expected in each sex if F1 females arecrossed to males of the same genotype as their father?a. Males – 1 : 0; females – 1 : 0b. Males – 1 : 1; females – 1 : 0c. Males – 0 : 1; females – 1 : 1d. Males – 1 : 1; females – 1 : 1n mice, the Ay allele of the agouti gene is recessive lethal, but it is dominant to wild type for yellow coat color. For an unlinked gene called C, cc makes no pigment and are albino while C_ mice will make pigment in in their coat. cc is epistatic to A or AY with regard to coat color, but not for viability. What phenotypic ratio would you expect from the progeny produced by two mice of the genotype: AAy Cc? (Note that “agouti” is the wild-type coat color.) 9 agouti : 3 black : 3 white : 1 yellow 3 agouti : 6 yellow : 3 white 12 yellow : 3 black: 1 brown 9 agouti : 3 yellow : 4 white 8 yellow : 3 black: 1 brownIn Drosophila flies, the allele b gives a black body, and the allele b+ gives brown, the wild-type phenotype. The allele wx of a separate gene gives waxy wings, and wx+ gives non-waxy. The allele cn of a third gene gives cinnabar eyes, and cn+ gives red. A female heterozygous for these three genes is testcrossed, and 745 progenies are produced which are phenotypically classified as follows: (see image) Make a linkage map of the three genes. Compute for interference and explain what the derived value means. Show complete solutions to support your answers
- A geneticist is using a three‑point testcross to map three linked Drosophila recessive mutations called a, b, and c, where a is associated with anomalous gait, b is associated with buckled wings, and c is associated with curved bristles. She first crosses homozygous anomalous, buckled flies to homozygous curved flies. Next, she testcrosses the F1 progeny to anomalous, buckled, curved flies. She obtains 1000 progeny distributed as shown. From this data, calculate the map distance between b and c. progeny curved 277 anomalous, buckled 283 wild type 5 anamalous, buckled, curved 5 buckled, curved 133 anomalous 127 anomalous, curved 86 buckled 84Vestigial wing is a recessive autosomal mutation in the fruit fly Drosophila melanogaster. Wild-type flies have red eyes, but another mutation, an X-linked recessive mutation causes white eyes. You cross a parental generation of males with vestigial wings with females that have white eyes. 1) What phenotypic ratio would you expect in the F1 generation from such a cross? What phenotypes do you observe in these flies? (e.g. males with red eyes and wild-type wings). 2) What phenotypic ratio would you expect in the F2 generation? What phenotypes do you observe in these flies?In Drosophila, the sepia mutation (se, chromosome 3, position 26) results in dark brown eyes, while cinnabar (cn, chromosome 2, position 57.5) results in bright orange-red eyes. True breeding, wild type females are mated with true breeding males homozygous recessive for both traits. Using Drosophila notation, diagram the P1 and F1 crosses. P1 F1 Fill in the chart with phenotypic ratios that would be expected in the F2 generation. Use the space provided to show your work. Phenotype Females Males Overall (♀and ♂) =1 =1