Will an insertion or a deletion of three nucleotides result in a frameshift mutation? Explain why or why not.

Duchenne muscular dystrophy is caused by a mutation in a gene that comprises 2.5 million base pairs and specifies a protein called dystrophin. However, less than 1% of the gene actually encodes the amino acids in the dystrophin protein. On the basis of what you now know about gene structure and RNA processing in eukaryotic cells, provide a possible explanation for the large size of the dystrophin gene.

By base-pair substitution, what are all the synonymouschanges that can be made starting with the codon CGG?

What are the three possible outcomes of point mutations?

What is the minimal number of insertions/deletions of nucleotides that would result in a frameshift mutation?

What are transposable elements? Explain the mechanism by which they move from one location to another in the genome.

why would a mutation complex 1 usually not result in immediate death ? And while blocking complex IV can result in immediate death ?

What feature of the –10 sequence makes it easy to unwind?

If the following nucleotide sequence, CTC/TGT/AAG/ACC/TTT experienced a mutation resulting in the deletion of the second cytosine in the first DNA triplet so the sequence is now CT_/TGT/AAG/ACC/TTT, what would be the amino acid sequence created from this mutated DNA strand? Table of mRNA codons UUA, UUG = leucine AGG, AGA = arginine %3D CAU, CAC = histidine GUU, GÜC, GUA = valine GAA. GAG=glutamic acid GCU, GUA, GUG = alanine GAU, GAC = asparagine GGU, GGC, GGA = glycine UCA, UCU =serine CGU, CGC, CGA = arginine

Which of the following mutations in the protein-coding region of a gene is more likely to lead to complete loss of function of the encoded protein: an insertion of six nucleotides or a deletion of two nucleotides? Briefly explain your answer.