why The chromatids formed byrecombination within the inversion loop of a pericentric inversionheterozygote are genetically unbalanced?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations
Section: Chapter Questions
Problem 14QP: Variations in Chromosome NumberAneuploidy Describe the process of nondisjunction and explain when it...
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why The chromatids formed by
recombination within the inversion loop of a pericentric inversion
heterozygote are genetically unbalanced?

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When the region between two breaks of the same chromosome rotate 180°, it results in chromosomal aberration called inversion. When the inversion occurs between the arms of the same chromosome, it is called paracentric but when inversion involves the centromere along with arms it is called pericentric. Heterozygotes for the inversion are generally phenotypic normal but their gamete’s quality and fertility can be affected causing the recombination in inverted region.

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