Why does hemoglobin have high affinity for oxygen in arterial blood and lower affinity in capillaries beds? Explain in terms of blood oxygen pressure.

When a person develops a fever, which of the following statements hemoglobin saturation are correct?  - Modify the structure of hemoglobin and decrease its affernity for O2 - Can shift the O2-hemoglobin dissociation curve to the right - Decrease O2 unloading occurs in the tissue  - Modify the structure of hemoglobin and increase its affernity for O2 - Can shift the O2 hemoglobin dissociation curve to the left - Enhance O2 unloading occurs in the tissue

Suppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m),and you begin to ponder the “big questions,” such as “What is the fractionalsaturation of the Dalai Lama’s hemoglobin?”(a) Assuming the Dalai Lama’s hemoglobin has a Hill coefficient = 3.2,and a P50 = 31 mm Hg, calculate the change in fractional O2 saturationof his hemoglobin going from his lungs (where PO2 = 85 mm Hg) to hiscapillaries (where PO2 = 25 mm Hg).(b) Why do you suppose the Dalai Lama’s hemoglobin has a P50 higher thannormal (where “normal” = 27 mm Hg)?

If there is increased hydrostatic pressure on the venous side of the capillaries leading to an increase in fluid moving into the tissues why would it cause ankle edema?  What role does the lung play in development of that increased hydrostatic pressure in terms of alveolocapillary membrane/lung changes.  What is the effect on oxygen diffusion from the alveolus, on pulmonary artery pressure and resultant changes to the right side of the heart)?

Carbon monoxide (CO) is a colorless, odorless gas produced during combustion of fuels (for example, by car engines and furnaces).  The following graph depicts an oxygen dissociation curve in the absence and presence of varying amounts of carbon monoxide. Based on these results, in the presence of 20% CO, when PO2 is 90mmHg you should expect each hemoglobin molecule to have _____ molecule(s) of O2 bound a) 1 b) 2 c) 3 d) 4