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- How are trisomies and monosomies related to deletions and duplications respectively? What is the significance of the following concepts in the image attached below and how are they linked (big picture)What is the difference between polygeny and pleiotropy?A normal mother has translocations on chromosomes 14:21. With respect to chromosomes 14:21, how many combinations of chromosomes are possible? How many gametes are viable? If the woman has children with an normal father, what is the probability that there is a daughter with Down Syndrome or a son with an unaffected phenotype?
- Why do you think there are no viable trisomies of chromosome 1?Explain how aneuploidy, deletions, and duplications cause geneticimbalances. Why do you think that deletions and monosomies aremore detrimental than duplications and trisomies?Which of the 6 modes is this pedigree and why? 1) Autosomal Dominant 2) Autosomal Recessive 3) X-linked Recessive 4) X - linked Dominant 5) Y-Linked 6) mt-Linked
- In the classic "X" figure of the chromosome, is the whole X from one parent, or is one side of the X from the mother and the other side from the father?Two phenotypically unaffected parents produce two children withfamilial Down syndrome. With regard to chromosomes 14 and 21,what are the chromosomal compositions of the parents?In a sample of 1000 patients with Down syndrome, a geneticist discovers that 95% of them are trisomic, while 5% have diploid number of chromosomes. Explain this discrepancy.