Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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**Question:**

Which statement is consistent with these data?

- ○ Compound X is an allosteric activator and Compound Z is an allosteric inhibitor.
  
- ○ Both Compound X and Compound Z are allosteric activators.

- ○ Both Compound X and Compound Z are allosteric inhibitors.

- ○ Compound X is an allosteric inhibitor and Compound Z is an allosteric activator.
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Transcribed Image Text:**Question:** Which statement is consistent with these data? - ○ Compound X is an allosteric activator and Compound Z is an allosteric inhibitor. - ○ Both Compound X and Compound Z are allosteric activators. - ○ Both Compound X and Compound Z are allosteric inhibitors. - ○ Compound X is an allosteric inhibitor and Compound Z is an allosteric activator.
### Enzymatic Activity with Compounds X and Z

This table examines how two compounds, X and Z, influence an enzyme's catalytic activity. These compounds are known to bind to the enzyme, but not at the active site.

#### Table: Effect of Compounds X and Z on Enzyme Activity

| Substrate Concentration (mM) | Rate of Enzyme-Catalyzed Reaction |
|------------------------------|-----------------------------------|
|                              | No Addition | + Compound X | + Compound Z |
| 0                            | 0           | 0            | 0            |
| 10                           | 50          | 60           | 10           |
| 20                           | 90          | 105          | 20           |
| 30                           | 110         | 115          | 28           |
| 40                           | 115         | 116          | 35           |

**Analysis of the Data:**

- **Without any addition**, the rate of the enzyme-catalyzed reaction increases with substrate concentration, demonstrating typical enzyme kinetics.
  
- **With Compound X**, the reaction rate is slightly elevated compared to no addition at each concentration level, suggesting that Compound X enhances the enzyme's activity.

- **With Compound Z**, the reaction rate is significantly lower than that with no addition, indicating that Compound Z reduces the enzyme's activity.

This data highlights how different compounds, even when not binding at the active site, can alter enzyme activity.
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Transcribed Image Text:### Enzymatic Activity with Compounds X and Z This table examines how two compounds, X and Z, influence an enzyme's catalytic activity. These compounds are known to bind to the enzyme, but not at the active site. #### Table: Effect of Compounds X and Z on Enzyme Activity | Substrate Concentration (mM) | Rate of Enzyme-Catalyzed Reaction | |------------------------------|-----------------------------------| | | No Addition | + Compound X | + Compound Z | | 0 | 0 | 0 | 0 | | 10 | 50 | 60 | 10 | | 20 | 90 | 105 | 20 | | 30 | 110 | 115 | 28 | | 40 | 115 | 116 | 35 | **Analysis of the Data:** - **Without any addition**, the rate of the enzyme-catalyzed reaction increases with substrate concentration, demonstrating typical enzyme kinetics. - **With Compound X**, the reaction rate is slightly elevated compared to no addition at each concentration level, suggesting that Compound X enhances the enzyme's activity. - **With Compound Z**, the reaction rate is significantly lower than that with no addition, indicating that Compound Z reduces the enzyme's activity. This data highlights how different compounds, even when not binding at the active site, can alter enzyme activity.
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