Concept explainers
Which primers are specific for UCP1 gene that locates in human mitpchondria?
What are primers?
Primers are oligonucleotides chains consisting of 10 to 60 base pairs utilized by all living organisms in the initiation of DNA replication.
What is UCP1 gene?
UCP1 gene encodes for mitochondrial uncoupling proteins and belongs to a gene family which is involved in the synthesis of Mitochondrila Anion Carrier Protein (MACP). Uncoupling proteins seperate the process of oxidative phosphorylation and ATP synthesis with energy emitted as heat.
Function of UCP1 gene
The uncoupling proteins encoded by this gene is responsible for mitochondrial proton leak, i.e., protons are transferred from the outer membrane to the inner membrane of the mitochondria and the anions are transferred from the inner membrane to the outer membrane of the mitochondria. They are involved in what is known as thermogenic respiration of the mitochondria, a special feature of brown adipose tissue, which emits heat (non-shivering thermogenesis).
Step by stepSolved in 3 steps
- IS APC a inflammotry gene and how does it chromosomal instability,arrow_forwardCertain hormones, such as epinephrine, can increase the levels ofcAMP within cells. Let’s suppose you pretreat cells with or withoutepinephrine and then prepare a cell extract that contains theCREB protein.You then use an electrophoretic mobility shift assay to analyzethe ability of the CREB protein to bind to a DNA fragmentcontaining a cAMP response element (CRE). Describe what theexpected results would be.arrow_forwardWhy are regulatory mutations at the mouse Sonic hedgehog gene dominant and viable? Why do coding mutations cause more widespread defects?arrow_forward
- How do we know that the mutant Bar-eye phenotype in Drosophila is due to a duplicated gene region rather than to a change in the nucleotide sequence of a gene?arrow_forwardBased on the partial diploid sketched shown in Figure 3, where cross-hatched rectangles and the red bar indicate mutations that inactivate that particular genetic element of the operon, state if expression of Lacl (Lac repressor) and LacZ (Beta-Galactosidase) is (select one of the options below for each genetic element and briefly justify your answer): constitutively ON (in the presence/absence of lactose) constitutively OFF (in the presence/absence of lactose) • inducible by lactose • not enough information given to conclude • none of the above FIGURE 3: lacl laco lacz- lacY lacl laco lacz lacYarrow_forwardIn a mutant mouse, it was discovered that a gene "W" is moved from its original chromosomal locus to the telomere region, where chromatin is packed into heterochromatin. Given what we have learned about eukaryotic gene regulation, can you speculate how the expression of gene W in the new mouse line would be changed as compare to the normal mouse? Question 18 options: elevated in the mutant mouse than in the wild-type mouse. cannot be determined. reduced in the mutant mouse than in the wild-type mouse. no change in the mutant mouse as compared to the wild-type mouse.arrow_forward
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education