Which one of the following statements about the molecular structure of phosphatidylcholine is TRUE? a. It contains an isoprene chain. b. It contains a polar hydrophobic head group. c. It contains at least five alkene double bonds. d. It contains a phosphodiester bond. e. It contains a glycosidic linkage.

Which of the following is incorrect about the collagen structure? a. The covalent cross-links between the individual chains stabilize the collagen structure b. None; all the other choices are correct The helical structure is cross-linked (with covalent bonds) at both ends Od. Gly residues are all located in the center of the helix (i.e. between the individual chains) C.

Glutamic acid (1one of the 20 amino acids) has a side- chain carboxyl group (COOH, pKa = 4.3) as shown in Figures 4.7 and 4.8 a. Write the chemical equation for the dissociation of the side chain COOH. Label the weak acid and the conjugate base. b. The Henderson-Hasselbalch Equation (shown below) can be used to determine the ionization status of a weak acid: pH = pKa + log [base] Use the Henderson Hasselbalch equation to determine whether the glutamic acid side chain [acid] • carboxyl group is protonated or deprotonated at physiological pH.

Which of the following drugs is a less potent microsomal triglyceride transfer protein (MTP) inhibitor, which reduces cholesterol levels? O Structure 1 (IC50 = 23 nM) O BMS-200150 (IC50 = 2.2 µM) O Hybrid Structure (IC50 = 12 nM) %3! O Hit compound (IC50 = 36 µM) %3D Lomitapide (IC50 = 0.5 nM)

For each of the following pairs of amino acids, identify the strongest type of intermolecular forces involved when the side chains interact.  Explain in terms of the chemical structures of the amino acid side chains.  Use the following list:  disulfide bridge, hydrogen bonding, hydrophobic interaction, or salt bridge. a) D and H b) C and C c) L and A d) G and S e) N and T

Identify the incorrect statement regarding the polypeptide, Myoglobin. Select one: a. The interaction between Myoglobin and O2 is homotopic in nature as indicated by a Hill coefficient n = : 1 b. Myoglobin is found predominantly in muscle tissue because it facilitates oxygen diffusion. c. The majority of Myoglobin's secondary structure is composed of alpha-helices d. Myoglobin has a higher affinity for oxygen than Hemoglobin e. Myoglobin serves as an oxygen storage protein as suggested by its hyperbolic binding of 02

Glucose polymers: Which of the following is/are FALSE? a. Beta-glycosidic bonds are found in starch, glycogen and chitin b. Beta-glycosidic bonds are found in cellulose and chitin C. alpha-glycosidic bonds are found in starch and glycogen d. alpha-glycosidic bonds are found in chitin and cellulose O b,c.d O a, b, c, d а, d a,b, d

Of the following cell membrane lipids, which one prefers to reside in the inner leaflet (or inner half) of the membrane bilayer, AND has an overall neutral charge at physiological pH (7.4)? a) PE (phosphatidylethanolamine) is inner-leaflet with an overall neutral charge at pH 7.4 b) SM (sphinogomyelin) is inner-leaflet with an overall neutral charge at pH 7.4 c) PS (phosephatidylserine) is inner-leaflet with an overall neutral charge at pH 7.4 d) PC (phosphatidylcholine) is inner-leaflet with an overall neutral charge at pH 7.4