Which one of the following nucleophiles will give mainly direct (1,2) addition in its reaction with the following conjugated enone? 8. a) CH;MgBr b) HBr c) CH3SH d) (CH3)½CULI

Rank the following nucleophiles in order from slowest SN2 reaction rate to fastest if DMSO is the solvent. ОН PH SH A B D E

Rank the attached compounds in order of increasing reactivity in asubstitution reaction with −CN as nucleophile.

Predict the products of the reaction. In the reaction above, the nucleophile reacts with the carbonyl carbon twice. State which reaction occurs faster, the first addition or the second addition, and explain why. 1) (2 equiv.) 2) H3O+, H₂O MgBr