What would happen to a human if this biosynthesis of amino acid pathway became disabled in a cell. Would anything not get made? Would anything build up?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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What would happen to a human if this biosynthesis of amino acid pathway became disabled in a cell. Would anything not get made? Would anything build up?

a-ketoglutarate
H* + NADPH + NH,
#1
NADP +
glutamate dehydrogenase
ATP + H* + NADPH
ADP + NADP
+ P.
glutamate
a-semialdehyde
(glutamic acid)
NH
# 2b
glutamate kinase dehydrogenase
# 3
ATP + NH
#2a
(spontaneous)
glutamate synthetase
ADP + P, +H +
Тext
glutamine
A'-pyrrolidine 5-carboxylate
H* + NADPH
# 4
NADP
pyrrolidine carbaxylate
reductase
NH
proline
Transcribed Image Text:a-ketoglutarate H* + NADPH + NH, #1 NADP + glutamate dehydrogenase ATP + H* + NADPH ADP + NADP + P. glutamate a-semialdehyde (glutamic acid) NH # 2b glutamate kinase dehydrogenase # 3 ATP + NH #2a (spontaneous) glutamate synthetase ADP + P, +H + Тext glutamine A'-pyrrolidine 5-carboxylate H* + NADPH # 4 NADP pyrrolidine carbaxylate reductase NH proline
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