Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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What structural consideration prevents the bases A and
G from forming a complementary base pair?
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- Draw the complete structure of the trinucleotide deoxyribo-oligonucleotide that is complementary to 5'dTdGdA3'. Draw this completely, showing all atoms of all parts of the structure.arrow_forwardHow many base pairs are in linker DNA?arrow_forwardWhy does DNA with a high A-T content have a lower melting temperature, Tm, than DNA with a high G-C content?arrow_forward
- How many GB is a DNA?arrow_forwardMoira, a biochemistry major, wanted to explore the shapes a single-stranded DNA molecule can take. She sketched the two shapes below. Her professor was impressed with Moira’s imagination and artistic ability, but she informed Moira that only one of her sketches was feasible. In the sketches, the lines indicate complementary base pairing. (d) Would a new double-stranded molecule assume the shape similar to one in the drawing? (e) Why or why not?arrow_forward1.3arrow_forward
- A primitive eukaryote was discovered that displayed a uniquenucleic acid as its genetic material. Analysis revealed the followingobservations:(a) X-ray diffraction studies display a general pattern similarto DNA, but with somewhat different dimensions and moreirregularity. (b) A major hyperchromic shift is evident upon heating andmonitoring UV absorption at 260 nm.(c) Base-composition analysis reveals four bases in the followingproportions:Adenine = 8% Hypoxanthine = 18%Guanine = 37% Xanthine = 37%(d) About 75 percent of the sugars are deoxyribose, whereas25 percent are ribose.Attempt to solve the structure of this molecule by postulating amodel that is consistent with the foregoing observations.arrow_forward1) Use the Leontis-Westhof base pair classification to identify the interaction occurring between each of the base pairs formed in the image below:arrow_forwardWhen an aromatic hydrocarbon intercalates between two stacked base pairs, what effect may there be on DNA structure?arrow_forward
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